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Background and purpose To investigate the usefulness of the revised Ability for Basic Movement Scale (ABMS II) for chronic-phase hospitalized patients, whether admitted owing to illness or injury. Methods A retrospective cohort of 176 consecutively admitted chronic care inpatients who underwent rehabilitation therapy between April 2021 and March 2023 was analyzed. Patients who died during admission, who were discharged within one month, or who had insufficient clinical data were excluded. Information on sex, age, residence before admission, and underlying diseases requiring physical rehabilitation therapy was collected. Daily living abilities were measured using the Functional Independence Measure (FIM) and Barthel Index (BI) scores during admission. Basic movement abilities were evaluated by two physical therapists using the ABMS II. The inter-rater reliability of ABMS II scores between therapists was analyzed using the weighted kappa coefficient. Spearman's rank correlation coefficient was used to evaluate the validity of ABMS II and its correlation with FIM/BI scores. This retrospective study was approved by the Ethics Committee of Hikari Hospital (Approval No. HH‑2024‑01). Results and discussion The cohort had a mean age of 84.8 ± 7.3 years, 56% were female, and baseline mean (SD) scores were 18.6 ± 7.6 for ABMS II, 53.8 ± 22.9 for FIM‑total, and 35.0 ± 26.7 for BI. The ABMS II showed excellent agreement (weighted kappa = 0.996; 95% confidence interval: 0.993-0.999) and strong positive correlations (0.743-0.819) with total FIM/BI scores. Conclusions The ABMS Ⅱ is useful for evaluating basic movement abilities in patients with chronic illnesses.
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http://dx.doi.org/10.7759/cureus.89373 | DOI Listing |
Eur J Neurol
September 2025
Department of Neuroscience 'Rita Levi Montalcini', University of Torino, Torino, Italy.
Background: The factors contributing to a poor response to subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) are not yet fully understood. Accordingly, predicting the outcome might be challenging particularly in those who display an optimal response to the Levodopa challenge test.
Objective: To determine which factors may contribute to poor outcome of STN-DBS in PD.
Mater Today Bio
October 2025
Radboud University Medical Center, Research Institute for Medical Innovation, Department of Medical BioSciences, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands.
Severe scarring is an inevitable consequence of large full-thickness skin wounds, often leading to long-term complications that affect patients' well-being and necessitate extended medical interventions. While autologous split-thickness skin grafts remain the clinical standard for wound treatment, they frequently result in contractures, excessive scarring, and the need for additional corrective procedures. To address these challenges, bioengineered skin substitutes capable of promoting efficient healing while reducing complications are highly desirable.
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
August 2025
Department of Hepatobiliary and Pancreatic Surgery, Peking University Shenzhen Hospital, 518036 Shenzhen, Guangdong, China.
Background: Lon protease 1 (LONP1), an adenosine triphosphate (ATP)-dependent protease encoded by nuclear DNA that is highly conserved, maintains the mitochondrial protein balance and regulates adaptive responses to cellular stress. LONP1 dysfunction ultimately results in various forms of cellular and tissue damage. The function of LONP1 in hepatocellular carcinoma (HCC) and how it affects HCC growth were investigated in this work.
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
August 2025
Department of Hepatobiliary Surgery, General Hospital of Ningxia Medical University, 750004 Yinchuan, Ningxia Hui Autonomous Region, China.
Background: Mediator complex subunit 10 (MED10) serves as a critical regulator of eukaryotic gene expression by facilitating RNA polymerase II activity. Our investigation aims to characterize MED10's functional contributions and underlying molecular pathways in hepatocellular carcinoma (HCC) development.
Methods: MED10 expression patterns in HCC and their correlation with clinicopathological parameters and patient outcomes were examined using bioinformatics databases and immunohistochemistry.
Clin Neurophysiol
September 2025
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Objective: To compare brain activity before voluntary movement and before the same movement when it was released from suppression. This study examined the Bereitschaftspotential (BP) and beta band event-related desynchronization (bERD) during active blink suppression, contrasting these with voluntary blinking, where these EEG correlates of motor preparation are well-established.
Methods: Fifteen healthy adults performed voluntary blink and blink suppression-release tasks with EEG recording.