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Purpose: Adolescence is a sensitive developmental period for the emergence of mental health challenges, but few multicountry qualitative studies explore how adolescents themselves understand these challenges. Through focus group discussions (FGDs) with adolescents across 13 countries, this study aimed to understand adolescents' perspectives on significant mental health challenges in their age group, key risk and protective factors, and principle coping strategies.
Methods: A total of 71 FGDs were conducted between February and June of 2021. Countries were selected to ensure geographic, economic, and cultural diversity, and included: Belgium, Chile, China, the Democratic Republic of the Congo, Egypt, Indonesia, Jamaica, Jordan, Kenya, Malawi, Sweden, Switzerland, and the United States. Within each country, FGDs were stratified by sex and age. FGDs were recorded, transcribed verbatim, and translated into English for analysis.
Results: Across countries, adolescents generally described and understood mental health challenges in terms of distress (e.g., sadness, loneliness, anger) rather than disorder (e.g., depression, anxiety). They emphasized the many contexts that drive mental health challenges, including family adversity, peer and school environments, pervasive violence, endemic poverty, and restrictive gender norms. They also discussed significant barriers to help-seeking, which frequently resulted in adolescents coping without what they perceived as sufficient support.
Discussion: Adolescents around the world highlighted numerous social and environmental factors that contribute to mental health challenges, as well as a pressing need for greater formal and informal supports. The nonclinical terminology favored by adolescents suggests that taking a purely diagnostic approach may exclude many adolescents in need of assistance.
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http://dx.doi.org/10.1016/j.jadohealth.2024.09.005 | DOI Listing |
Eat Disord
September 2025
Center for Eating and feeding Disorders Research (CEDaR), Psychiatric Center Ballerup, Mental Health Services in the Capital Region of Denmark.
Proc Natl Acad Sci U S A
September 2025
Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240.
Major depressive disorder affects millions worldwide, yet current treatments require prolonged administration. In contrast, ketamine produces rapid antidepressant effects by blocking spontaneous N-Methyl-D-Aspartate (NMDA) receptor signaling, which lifts the suppression of protein synthesis and triggers homeostatic synaptic plasticity. Here, we identify a parallel signaling pathway involving metabotropic glutamate receptor 5 (mGluR5) that promotes rapid antidepressant-like effects.
View Article and Find Full Text PDFJAMA Netw Open
September 2025
Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Lübeck, Lübeck, Germany.
Importance: Patients with inflammatory rheumatic diseases (IRDs) frequently experience psychological distress; however, access to psychological support remains limited.
Objective: To investigate the effectiveness of a digital psychological intervention for individuals with IRDs.
Design, Setting, And Participants: Participants aged 18 years or older were recruited across Germany between February 22 and June 4, 2024, if they had been diagnosed with rheumatoid arthritis, psoriatic arthritis, or systemic lupus erythematosus and reported psychological distress and reduced quality of life.
J Gambl Stud
September 2025
Department of Psychology and Azrieli Israel Center for Addiction and Mental Health, The Hebrew University of Jerusalem, Jerusalem, Israel.
Research suggests that Problem Gambling (PG) may result from maladaptive emotional regulation strategies aimed at escaping emotions and stress caused by negative life events and trauma. The current study, aimed to examine the effect of exposure to the mass trauma of October 7, 2023 terror attack and the consequent Swords of Iron war in Israel, and difficulties in emotional regulation on PG. We utilized longitudinal data of self-reports in the Problem Gambling Severity Index collected before the terror attack (April 2022) and during the Swords of Iron war (December 2023, March 2024, June 2024; N = 899) from a large sample of adult Jewish Israelis.
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