Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The anticoagulant proteins antithrombin (AT), protein C (PC), protein S (PS), and tissue factor pathway inhibitor (TFPI) are physiological regulators of the blood coagulation pathway and have complex roles in causing or modifying the severity of bleeding and clotting disorders. The anticoagulant activity, as well as alternative physiological functions, of these proteins also impact many other diseases beyond bleeding and clotting disorders. We searched PubMed for articles published between 2018 and early 2025 that pertained to alternative functions of these physiological anticoagulants in clinical disease and selected therapeutic applications in the following categories: cancer, cardiovascular disease, novel therapeutics, pregnancy health, inflammation and infection, blood-brain barrier protection, stroke, novel developments in thrombosis, and endothelial and platelet interactions. This review highlights recently identified physiological implications of AT, PC, PS, and TFPI functions that present an exciting therapeutic avenue for a diverse array of human diseases.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jtha.2025.08.014 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Progestogens and androgens influence root morphology of angiosperms in a brassinosteroid-independent manner.
Plant J
September 2025
Plant Physiology, Matthias Schleiden Institute for Genetics, Bioinformatics and Molecular Botany, Friedrich Schiller University Jena, 07743, Jena, Germany.
Progestogens and androgens are steroids found in a wide range of plants, but little is known about their physiological functions. In this study, we sowed seeds of angiosperms on progestogen- and androgen-containing medium and analysed their morphological effects. We further investigated the effects of progesterone and testosterone on brassinosteroid profiles and gene expression in A.
View Article and Find Full Text PDFMenopause and the voice: a narrative review of physiological changes, hormone therapy effects, and treatment options.
Menopause
September 2025
Department of Speech Language Pathology and Audiology, Northeastern University, Boston, MA.
Importance And Objective: Voice changes during menopause affect patients' communication and quality of life. This narrative review aims to provide a comprehensive exploration of voice changes during menopause. It presents objective and subjective/symptomatic changes as well as treatment options for this population.
View Article and Find Full Text PDFNutritional supplement containing a nuclear fraction of bovine thymus gland increases the circulating levels of spermidine.
PLoS One
September 2025
Nutrition Innovation Center, Standard Process Inc., Kannapolis, North Carolina, United States of America.
Polyamines (PAs), including spermidine, spermine and their precursor, putrescine, are ubiquitous molecules that are vital for a variety of physiological processes. Recently, PAs gained research attention because of their roles in promoting longevity and preventing age-related diseases. Circulating and tissue levels of PAs appear to decline with age, while higher intake of PAs in humans is correlated with better health during aging.
View Article and Find Full Text PDFThe flavonoid rutin protects against imidacloprid-induced osmotic and electric disruptions in Africanized honey bees.
PLoS One
September 2025
Departamento de Biología, Escuela de Ciencias e Ingeniería, Universidad del Rosario, Bogotá, Colombia.
Honey bees (Apis mellifera) are essential pollinators threatened by sublethal effects of pesticides such as imidacloprid, a widely used neonicotinoid that disrupts the central nervous system. However, many of the systemic effects are poorly understood, especially on the physiological homeostasis of the honey bee. We evaluated the effects of oral administration of imidacloprid and the flavonol rutin on the properties of extracellular fluid (ECF) in Apis mellifera.
View Article and Find Full Text PDFIntroduction: Frailty, characterized by a reduction in intrinsic capacity across multiple physiological systems, is a key concern in healthy aging. Insight in the trajectory of an individual's functional ability and intrinsic reserve capacity in a relatively younger population of older adults is lacking. This study aims to investigate the early stages of frailty by tracking trajectories of physical indicators of intrinsic capacity before frailty becomes clinically evident.
View Article and Find Full Text PDF