Of hope from fading will: Interoceptive signaling and the behavioral biology of cachexia.

Neuron

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA; Northwell Health, New Hyde Park, NY 11042, USA. Electronic address:

Published: September 2025


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Article Abstract

This NeuroView explores how systemic cancer signals induce behavioral changes via brain-body communication pathways, framing cachexia as an adaptive yet unsustainable interoceptive response. Recognizing patient-reported symptoms as biological signals offers new avenues for intervention and understanding brain-disease interactions.

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http://dx.doi.org/10.1016/j.neuron.2025.06.019DOI Listing

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