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Article Abstract
Aim: To investigate the protective and therapeutic effects of dexpanthenol in experimental global cerebral ischemia-reperfusion injury Material and Methods: 32 female Wistar-Albino rats were used and the rats were divided into 4 groups (Sham, Ischaemia Reperfusion (IR), IR+Dexpantol (IR+DXP) and DXP+IR), each containing 8 animals. At the end of 72 hours of reperfusion, the rats were decapitated after performing the rota-rod and acceler-rod tests, and their brain tissues were removed, histopathologically examined and superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH) and malonyldialdehyde (MDA) levels were evaluated.
Results: In this study, motor skill functions deteriorated in the ischemia-reperfusion (IR) group compared to the Sham group, while significant improvements were observed in both the IR + DXP and DXP + IR groups (p 0.05). There were no notable differences in CAT, SOD, and GPx enzyme levels among the groups (p 0.05). However, malondialdehyde (MDA) levels increased in the IR group but decreased significantly in the IR + DXP group (p 0.05). Similarly, glutathione (GSH) levels were lower in the IR group but higher in the IR + DXP group (p 0.05). Neuronal degeneration also significantly increased in the IR group, but decreased in the IR + DXP group (p 0.05).
Conclusion: Overall, these findings suggest that dexpanthenol has a neuroprotective effect, particularly when administered during the reperfusion phase, effectively improving motor skills and reducing neuronal damage.
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Aim: To investigate the protective and therapeutic effects of dexpanthenol in experimental global cerebral ischemia-reperfusion injury Material and Methods: 32 female Wistar-Albino rats were used and the rats were divided into 4 groups (Sham, Ischaemia Reperfusion (IR), IR+Dexpantol (IR+DXP) and DXP+IR), each containing 8 animals. At the end of 72 hours of reperfusion, the rats were decapitated after performing the rota-rod and acceler-rod tests, and their brain tissues were removed, histopathologically examined and superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH) and malonyldialdehyde (MDA) levels were evaluated.
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