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Principles of Coronary Sinus Narrowing to Relieve Myocardial Ischemia and Improve Angina.
Am J Cardiol
September 2025
Tel Aviv Medical Center, 6 Weizmann St, Tel Aviv, 6423906, Israel. Electronic address:
Effective therapy for patients suffering from refractory angina remains a major unmet need. Chronic angina, which is refractory to medical and interventional therapies, affects patients who are not suitable for revascularization, patients following successful revascularization, and patients with coronary microvascular dysfunction. Coronary sinus (CS) narrowing has been studied as a potential therapy for patients with angina.
View Article and Find Full Text PDFWhen chest pain is not what it seems: time for right diagnosis and right treatment-a case report.
Eur Heart J Case Rep
September 2025
Department of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go A. Gemelli 1, Rome 00168, Italy.
Background: Chest pain is a common reason for emergency department (ED) visits, yet not all cases are attributable to coronary artery disease (CAD). The 2024 European Society of Cardiology (ESC) guidelines emphasize the importance of invasive coronary function testing in patients with angina and non-obstructive coronary arteries. Understanding alternative causes of chest pain is crucial for appropriate diagnosis and management.
View Article and Find Full Text PDFAngina with non-obstructive coronary arteries: a success story.
Eur Heart J
September 2025
Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy.
Chest pain patterns and coronary microvascular function in non-obstructive coronary artery disease.
EuroIntervention
September 2025
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Background: Coronary microvascular dysfunction (CMD) is a common cause of chest pain (CP) in patients with angina and non-obstructive coronary arteries (ANOCA). Although both CMD and CP have distinct classifications, the relationship between them remains insufficiently understood.
Aims: This study investigated the relationship between CMD and CP patterns and their prognostic impact in ANOCA patients.
Introduction: Obstructive coronary artery disease (CAD) has long been recognized as the primary mechanism underlying myocardial ischaemia. However, up to 50 % of patients with angina and objective evidence of ischaemia present with non-obstructed coronary arteries (INOCA) in the coronary angiography, falling under the umbrella term INOCA, a heterogeneous group that remains frequently underdiagnosed and undertreated. Performing a coronary function test (CFT) enables us to diagnose and stratify these patients into different endotypes and start a targeted medical therapy.
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