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Introduction: Syphilis in pregnancy, caused by Treponema pallidum, can be vertically transmitted, leading to serious neonatal complications such as preterm birth, stillbirth, and neonatal death. Despite global efforts to reduce its prevalence, challenges such as inadequate antenatal screening and delayed treatment persist. Early diagnosis and treatment are crucial to preventing adverse outcomes.
Case Illustration: A 24-year-old pregnant woman (G3P2A0) was admitted at 29-30 weeks of gestation with premature rupture of membranes and labor contractions. She had been diagnosed with syphilis at 28 weeks but had not received treatment. The baby boy was delivered prematurely and suffered from severe asphyxia and respiratory distress, requiring resuscitation. Sadly, he passed away three hours after birth. The mother was discharged after receiving the first dose of syphilis treatment.
Conclusion: This case highlights the critical importance of early syphilis screening and timely treatment during pregnancy to prevent adverse maternal and neonatal outcomes. Delayed intervention in this case contributed to a poor prognosis. Comprehensive antenatal screening and prompt follow-up care are essential to reducing the risk of congenital syphilis and its complications.
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http://dx.doi.org/10.2147/IMCRJ.S541737 | DOI Listing |
Transfusion
September 2025
Medical Affairs and Innovation, Canadian Blood Services, Ottawa, Ontario, Canada.
Introduction: Donors are deferred if they are on antiretroviral medications (ARV) as post-exposure or pre-exposure prophylaxis (PEP or PrEP) for human immunodeficiency virus (HIV). We assessed donor compliance by measuring ARV levels in selected anonymized donor samples collected from September 22, 2022 to December 31, 2024, almost all after the introduction of sexual risk behavior screening.
Methods: EDTA plasma samples collected at the time of donation (retention samples) were retrieved, frozen, and shipped for measurement of tenofovir and emtricitabine.
Int Med Case Rep J
August 2025
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.
Introduction: Syphilis in pregnancy, caused by Treponema pallidum, can be vertically transmitted, leading to serious neonatal complications such as preterm birth, stillbirth, and neonatal death. Despite global efforts to reduce its prevalence, challenges such as inadequate antenatal screening and delayed treatment persist. Early diagnosis and treatment are crucial to preventing adverse outcomes.
View Article and Find Full Text PDFBMJ Open
September 2025
Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaounde, Cameroon.
Objective: The study was conducted to assess the diagnostic performance of the Hightop Syphilis Rapid Diagnostic Test (RDT) in comparison with the ELISA test used as a reference method.
Design: A laboratory-based cross-sectional and comparative study was conducted to assess the diagnostic performance of the Hightop Syphilis RDT.
Setting: Blood samples obtained from adult participants in eight health facilities were analysed at the National Public Health Laboratory (NPHL), Ministry of Public Health, Yaounde, Cameroon.
N Engl J Med
September 2025
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD.
Background: Controversy persists regarding the appropriate duration of therapy with benzathine penicillin G in persons with early (i.e., primary, secondary, or early latent) syphilis ( infection).
View Article and Find Full Text PDFRev Bras Enferm
September 2025
Universidade Federal de São Paulo. São Paulo, São Paulo, Brazil.
Objectives: to investigate factors associated with willingness to know one's syphilis serological status among higher education students.
Methods: a cross-sectional and analytical study conducted with higher education students in Portugal. Data collection was carried out through an online questionnaire.