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The abnormal or irregular growth of cells in regions of the human body that affects surrounding tissues is termed a tumor. Brain tumors are among the most dangerous and life-threatening types of tumors, arising from the abnormal growth of cells within the brain. However, existing detection methods often suffer from limitations, such as poor noise handling in MRI images, inaccurate segmentation, and low generalization across varying datasets. To resolve these difficulties, in this article, the convolutional-adaptive neuro fuzzy inference system (Conv-ANFIS) approach is devised for brain tumor detection from the magnetic resonance imaging (MRI) brain images. Conv-ANFIS is a combined model that merges a convolutional neural network (CNN) with an adaptive neuro-fuzzy inference system (ANFIS) and helps improve brain tumor detection accuracy. Initially, the de-noising of acquired input MRI images is done by applying a non-local means (NLM) filter. The skull portions are removed from the de-noised MRI image. Next, segmentation is performed by applying the structure correcting adversarial network (SCAN) to the image after skull removal. SCAN is a deep learning-based segmentation model designed for medical imaging. It ensures the accurate detection of tumors in MRI images. Subsequently, the features are mined from the segmented images by utilizing different feature extractors. Finally, the brain tumor is identified using the designed Conv-ANFIS model from the extracted feature vector. Furthermore, the effectiveness of Conv-ANFIS in detection is confirmed, achieving a recall of 92.31%, precision of 90.13%, and an F1-score of 91.21%, outperforming existing approaches.
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http://dx.doi.org/10.1002/nbm.70124 | DOI Listing |
PLoS One
September 2025
Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Background: Attention to existential needs has become part of daily treatment. Studies have described the concepts of existential experiences and existential interventions. However, a consensus or conceptual clarity regarding an existential approach in cancer patients is currently missing.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Kraków 30-387, Poland.
The multifunctional systems presented here introduce an innovative and deeply thought-out approach to the more effective and safer use of temozolomide (TMZ) in treating glioma. The developed hydrogel-based flakes were designed to address the issues of local GBL therapy, bacterial neuroinfections, and the bleeding control needed during tumor resection. The materials obtained comprise TMZ and vancomycin (VANC) loaded into cyclodextrin/polymeric capsules and embedded into gelatin/hyaluronic acid/chitosan-based hydrogel films cross-linked with genipin.
View Article and Find Full Text PDFJ Neurooncol
September 2025
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Purpose: Glioblastoma (GBM) remains one of the most aggressive primary brain tumors with poor survival outcomes and a lack of approved therapies. A promising novel approach for GBM is the application of photodynamic therapy (PDT), a localized, light-activated treatment using tumor-selective photosensitizers. This narrative review describes the mechanisms, delivery systems, photosensitizers, and available evidence regarding the potential of PDT as a novel therapeutic approach for GBM.
View Article and Find Full Text PDFJ Neurooncol
September 2025
Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Purpose: NOTCH3 is increasingly implicated for its oncogenic role in many malignancies, including meningiomas. While prior work has linked NOTCH3 expression to higher-grade meningiomas and treatment resistance, the metabolic phenotype of NOTCH3 activation remains unexplored in meningioma.
Methods: We performed single-cell RNA sequencing on NOTCH3 + human meningioma cell lines.
Neurosurg Rev
September 2025
Service de Neurochirurgie, GHU-Paris Psychiatrie et Neurosciences, Site Sainte Anne, Paris, F-75014, France.
Awake craniotomy is the gold standard to achieve maximal safe resection of brain lesions located within eloquent areas. There are no established guidelines to assess patient's eligibility for awake craniotomy by weight class. This study assesses feasibility, safety, and efficacy of awake surgery by weight classes through an observational, retrospective, single-institution cohort analysis (2010-2024) of 526 awake craniotomies.
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