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Background: Unstable osteochondritis dissecans of the capitellum (OCD-C) is most commonly treated with debridement and marrow stimulation. This treatment has historically been associated with suboptimal return to high-demand upper extremity sports and persistent elbow pain. Fresh osteochondral allograft transplant (OCAlloT) is an alternative treatment that restores subchondral bone and articular cartilage without the donor site morbidity that is associated with autograft harvest.
Purpose: To evaluate the outcomes of OCAlloT in pediatric patients with unstable OCD-C ≥10 mm in diameter.
Study Design: Case series; Level of evidence, 4.
Methods: A single-center prospective study was performed of pediatric patients younger than 19 years who had unstable OCD-C ≥10 mm in diameter treated with primary fresh OCAlloT using precut osteochondral allograft cores. Postoperative magnetic resonance imaging (MRI) was obtained to assess graft incorporation. Patient-reported outcome (PRO) scores were obtained preoperatively and then annually after surgery. Minimum follow-up duration was 2 years.
Results: The study included 28 elbows in 26 patients, mean age 13.5 years (range, 11.3-17.1 years). The most common primary sports were gymnastics and baseball. OCD location was far-lateral in 6 elbows (21%). Mean OCD size was 11 mm in width, 12 mm in length, and 7 mm in depth. Twenty-four elbows (86%) were treated with a single allograft plug. Median OCAlloT size was 11.8 mm in diameter. Mean follow-up duration was 40 months. No infections or graft failures occurred. Two elbows (7%) had a secondary surgery for arthrofibrosis and posterolateral synovial impingement. Postoperative MRI scans were obtained in 19 elbows (68%) and demonstrated a high degree of graft incorporation. All patients had preoperative, 1-year, and 2-year PRO scores, and the 1- and 2-year PRO scores showed significant improvements compared with preoperative PRO scores. A total of 23 elbows (82%) had returned to sports at 1 year, and 27 (96%) had returned to sports at 2 years.
Conclusion: OCAlloT for treatment of OCD-C was associated with low rates of complications, excellent graft incorporation, high elbow function, patient satisfaction, and overall high rates of return to sports at 2 years.
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http://dx.doi.org/10.1177/03635465251366903 | DOI Listing |
N Am Spine Soc J
September 2025
Orthopedic Research Department, 31 Seymour St. Hartford HealthCare Bone and Joint Institute, Hartford, CT, 06106 United States.
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View Article and Find Full Text PDF3 Biotech
October 2025
Department of Oncology, The Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, China.
Unlabelled: By integrating single-cell and bulk RNA-sequencing data for esophageal cancer (ESCA), we developed and validated a seven-macrophage-gene prognostic signature (FCN1, SCARB2, ATF5, PHLDA2, GLIPR1, CHORDC1, and BCKDK). This signature effectively stratified patients into high- and low-risk groups with significantly different overall survival, achieving area under the curve (AUC) values greater than 0.7 for 1-, 2-, and 3-year survival prediction.
View Article and Find Full Text PDFOrthop J Sports Med
September 2025
The Jameson Crane Sports Medicine Institute at The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Background: Lateral meniscal oblique radial tears (LMORTs) of the posterior horn typically occur in the setting of an acute anterior cruciate ligament (ACL) rupture. Despite publications pertaining to the prevalence, biomechanics, and surgical repair techniques of LMORTs, studies reporting mid-term outcomes after LMORT repair are lacking.
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Front Public Health
September 2025
Neurosciences Axis, Centre de Recherche du Centre Hospitalier Universitaire (CRCHU) de Québec-Université Laval, Québec City, QC, Canada.
Introduction: Preventive measures have been implemented in hospitals during COVID-19, but how these guidelines affected mental health among healthcare workers (HCWs) remains to be determined. On another note, reliable psychological and blood-based markers are needed to promptly identify HCWs at-risk to develop distress. Extracellular vesicles (EVs) originating from brain cross the blood-brain barrier and are detectable in blood, giving them a highly valuable potential for biomarker discovery.
View Article and Find Full Text PDFHeart Rhythm O2
August 2025
Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
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