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The use of a wire probe is a robust method for beam profile measurement, but it can only provide a 1D projection of the beam profile. In this study, we developed a novel method for measuring a beam projected from a 360° angle by a dual-axis rotation of a wire and obtaining a complete 2D profile via image reconstruction. We conducted a proof-of-principle study using an Ar+ ion beam and optimized the reconstruction algorithm. The experimental results showed that the use of the order subsets expectation maximization algorithm is the most reasonable method, providing a highly accurate absolute 2D beam profile within a processing time on the millisecond scale. Furthermore, analysis of 2D profiles at different probing positions provided the beam direction and the phase-space distribution. This versatile method can be applied to various fields of particle beam technologies, such as particle therapy, semiconductor processing, and material analysis, as well as basic scientific research.
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http://dx.doi.org/10.1063/5.0271359 | DOI Listing |
JCO Clin Cancer Inform
August 2025
Telperian, Austin, TX.
Purpose: Lymphocytes play critical roles in cancer immunity and tumor surveillance. Radiation-induced lymphopenia (RIL) is a common side effect observed in patients with cancer undergoing chemoradiation therapy (CRT), leading to impaired immunity and worse clinical outcomes. Although proton beam therapy (PBT) has been suggested to reduce RIL risk compared with intensity-modulated radiation therapy (IMRT), this study used Bayesian counterfactual machine learning to identify distinct patient profiles and inform personalized radiation modality choice.
View Article and Find Full Text PDFJ Chem Phys
September 2025
Smoluchowski Institute of Physics, Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.
An improved rotational characterization of the E3Σ1+(63S1) Rydberg state of the CdAr diatom produced in a supersonic beam and studied using laser induced fluorescence (LIF) excitation spectra is presented. As an example, the spectra of the E3Σ1+←A3Π0+(53P1) transition, originating from the excitation of a single 116Cd40Ar isotopologue, are recorded and analyzed. In the experiment, the optical-optical double resonance method is employed, utilizing the E3Σ1+(υ')←A3Π0+(53P1)(υ″=6)←X1Σ0+(υ=0) scheme.
View Article and Find Full Text PDFRev Sci Instrum
September 2025
National Synchrotron Radiation Research Center, Hsinchu 30076, Taiwan.
In this work, we developed a vacuum-compatible long trace profiler (LTP) for in situ metrology of ultra-precise x-ray optics within synchrotron vacuum chambers. Although traditional LTPs operate ex situ under atmospheric pressure, earlier optical setups-such as that by Qian et al.-performed in situ distortion measurements by directing laser beams through vacuum viewports.
View Article and Find Full Text PDFMol Pharm
September 2025
Key Laboratory of Radiopharmaceuticals of Ministry of Education; NMPA (National Medical Products Administration) Key Laboratory for Research and Evaluation of Radiopharmaceuticals; College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China.
2-[F]Fluoro-2-deoxy-d-glucose ([F]FDG) is the most extensively utilized tumor imaging agent in clinical positron emission tomography (PET) applications. Nevertheless, no radiolabeled glucose derivatives for single-photon emission computed tomography (SPECT) imaging have achieved clinical usage comparable to that of [F]FDG. Technetium-99m is a common single-photon-emitting radionuclide used in clinical practice and has potential for the development of novel radiopharmaceuticals.
View Article and Find Full Text PDFJ Appl Clin Med Phys
September 2025
Department of Radiology, University of Kentucky, Lexington, Kentucky, USA.
Background: Digital dynamic radiography (DDR), integrated into Konica Minolta's portable mKDR system, provides dynamic imaging for pulmonary, orthopedic, and interventional applications. While DDR is not classified as fluoroscopy, its use of pulsed x-rays for cine-like image sequences raises concerns about radiation exposure and shielding, particularly given the absence of a primary beam stop, high output capabilities, and increasing clinical adoption.
Purpose: To characterize the primary and scatter radiation output of a DDR system and compare it against commonly used mobile C-arm fluoroscopy units, and to evaluate shielding requirements and potential occupational exposure risks associated with DDR use.