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The hydrologic cycle is increasingly disrupted due to the rising human population and the associated decline in forest trees. The rationale of this work was to address the disruption in the hydrologic cycle, which is caused by the dual adverse effects of human population growth: reducing forestry trees and diminishing clouds' formation. The proposed model assumes that the density of forestry trees decreases due to harvesting activities to fulfill the resource demands of human population. Additionally, it posits that the transpiration from forestry trees contributes to an increased density of vapor clouds' formation, while population growth adversely impacts the natural formation rate of vapor clouds. The model was analyzed by employing qualitative analysis, demonstrating the feasibility and stability of equilibrium solutions. Furthermore, to capture the consequences of environmental fluctuations on the model's dynamics, the proposed deterministic model was extended to a stochastic framework. The analytical and numerical work sought to provide the directives for understanding and mitigating the adverse effects of human activities on the hydrologic cycle, promoting sustainable practices to restore ecological equilibrium. Results of the model analysis reveal that an increase in human population leads to a decline in both rainfall and forestry trees. However, reforestation with high-transpiration tree species can mitigate rainfall decline and restore balance to the hydrologic cycle. Moreover, the maximum density of forest trees is achieved when the utility of rain by the forest trees and the natural formation of vapor clouds are maximal. Also, the minimal anthropogenic hindrance in reducing the natural formation of vapor clouds, combined with the maximal efficiency of vapor clouds to naturally convert into raindrops, facilitates maximum rainfall.
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http://dx.doi.org/10.3934/mbe.2025076 | DOI Listing |
Cereb Cortex
August 2025
Nencki Institute of Experimental Biology, PAS, 3 Pasteur Street, 02-093 Warsaw, Poland.
In the visual cortices, receptive fields (RFs) are arranged in a gradient from small sizes in the center of the visual field to the largest sizes at the periphery. Using functional magnetic resonance imaging (fMRI) mapping of population RFs, we investigated RF adaptation in V1, V2, and V3 in patients after long-term photoreceptor degeneration affecting the central (Stargardt disease [STGD]) and peripheral (Retinitis Pigmentosa [RP]) regions of the retina. In controls, we temporarily limited the visual field to the central 10° to model peripheral loss.
View Article and Find Full Text PDFJAMA Netw Open
September 2025
Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Importance: Patients with advanced cancer frequently receive broad-spectrum antibiotics, but changing use patterns across the end-of-life trajectory remain poorly understood.
Objective: To describe the patterns of broad-spectrum antibiotic use across defined end-of-life intervals in patients with advanced cancer.
Design, Setting, And Participants: This nationwide, population-based, retrospective cohort study used data from the South Korean National Health Insurance Service database to examine broad-spectrum antibiotic use among patients with advanced cancer who died between July 1, 2002, and December 31, 2021.
JAMA Netw Open
September 2025
Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City.
Importance: Advances in diagnostics have enabled the detection of more gastrointestinal pathogens, but misuse of diagnostics can lead to inappropriate antibiotic use and excess financial burdens. Ensuring appropriate use of diagnostics is crucial for optimizing patient care and promoting stewardship of health care resources.
Objective: To elicit parents' and clinicians' perspectives on expectations for care of pediatric diarrhea with a focus on diagnostic testing and to evaluate the potential for an electronic clinical decision support tool (ECDST) to improve appropriate use of diagnostics.
JAMA Netw Open
September 2025
Centre de recherche intégrée pour un système apprenant en santé et services sociaux, Centre intégré de santé et de services sociaux de Chaudière-Appalaches, Lévis, Québec, Canada.
Importance: Caregivers of community-dwelling older adults play a protective role in emergency department (ED) care transitions. When the demands of caregiving result in caregiver burden, ED returns can ensue.
Objective: To develop models describing whether caregiver burden is associated with ED revisits and hospital admissions up to 30 days after discharge from an initial ED visit.
Purpose: The purpose of this document is to review current methods for cervical ripening and to summarize the effectiveness of these approaches based on appropriately conducted outcomes-based research. This document focuses on cervical ripening in individuals with term, singleton, vertex pregnancies with membranes intact, because this is the population in whom most studies were conducted. For more information on recommended timing of delivery based on maternal, fetal, and obstetric conditions and on labor management, refer to: American College of Obstetricians and Gynecologists (ACOG) Committee Opinion No.
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