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, formerly known as , is a motile Gram-negative, facultatively anaerobic bacterium with coccoid rod morphology. Although previously considered non-pathogenic, emerging case studies indicate its potential role in causing serious infections, including bacteraemia, meningitis, sepsis, and implant-associated infections. This study presents the first whole-genome sequence of of Indian origin, isolated from the stool sample of a tuberculosis patient undergoing treatment. Sequencing was performed using the Illumina NextSeq 2000 and Oxford Nanopore PromethION platforms. The genomic data provides valuable insights into the antimicrobial resistance traits and mobile genetic elements of the bacterium, contributing to a deeper understanding of its pathogenic potential.
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http://dx.doi.org/10.1016/j.dib.2025.111983 | DOI Listing |
Background: Actinomyces graevenitzii is a relatively uncommon Actinomyces species, which is an oral species and predominantly recovered from respiratory locations [1,2]. It is a gram-positive anaerobic bacteria or microaerobic filamentation bacteria, which can induce pyogenic and granulomatous inflammation characterized by swelling and concomitant pus, sinus formation, and the formation of yellow sulfur granules. All tissues and organs can be infected; the most common type involves the neck and face (55%), followed by the abdominal and pelvic cavities (20%).
View Article and Find Full Text PDFMonaldi Arch Chest Dis
September 2025
Department of Community Medicine, K S Hegde Medical College, Mangaluru, Karnataka.
Fiber-optic bronchoscopy (FOB) plays a crucial role in the diagnosis and management of various pulmonary diseases by offering direct visualization of the airways and enabling targeted sampling for microbiological and histopathological evaluation. This study aimed to assess the clinical, radiological, microbiological, and histopathological profiles of patients undergoing FOB. A retrospective analysis of 103 participants who underwent the procedure over one year was conducted.
View Article and Find Full Text PDFBMJ Public Health
August 2025
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Introduction: Hepatitis C virus (HCV) infection is a substantial public health concern, particularly among individuals with opioid addiction. The methadone maintenance treatment (MMT) programmes serve as a harm reduction strategy to mitigate HIV disease spread, yet the risk of HCV infection remains high within these settings. Accurate risk prediction for HCV seroconversion is therefore crucial for improving patient outcomes.
View Article and Find Full Text PDFFront Neurol
August 2025
Department of Infectious Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Aims: In this study, we aimed to analyze the pathogen detection results in spinal infections using percutaneous CT-guided biopsy or transforaminal endoscopic spinal biopsy.
Methods: This is a retrospective observational study of patients who underwent biopsy for spinal infection at Shanghai Sixth People's Hospital between December 2020 and June 2024. Data on demographics, clinical presentations, radiological findings, and histopathology were collected from medical records.
Ther Innov Regul Sci
September 2025
Fiocruz Brasilia, ColLaboratory of Science, Technology, Innovation and Society (CTIS), Brasilia, DF, Brazil.
Purpose: To identify and review scientific evidence from experimental studies utilizing unmanned aerial vehicles (UAVs) to transport samples for the diagnosis of COVID-19 and tuberculosis (TB). This exploratory study aims to support the future development of UAVs for transporting biological samples within the Brazilian Unified Health System (SUS).
Methods: This scoping review defined its eligibility criteria using the PECO acronym, focusing on: Population: biological samples for diagnosing COVID-19 or TB; Exposure: UAV transportation; Comparator: land transportation; Outcomes: Cost, effectiveness, methods for sample preservation, flight parameters (time, altitude, speed, distance), and quality of transported samples.