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Article Abstract
We developed a nanoparticle based on a cell-penetrating peptide-PROTAC conjugate with a disulfide linker, , and dextran sulfate, enhancing cellular uptake and BRD4 degradation. This delivery platform significantly improves PROTAC bioavailability and offers a promising strategy to overcome membrane permeability challenges for targeted protein degradation.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394912 | PMC |
| http://dx.doi.org/10.1039/d5cb00196j | DOI Listing |
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