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Appendiceal neoplasms (ANs) are rare and often mimic acute appendicitis, complicating timely diagnosis. We report a unique case of a 57-year-old male presenting with right lower quadrant pain, found on imaging to have a ruptured appendiceal mucocele. He underwent open right hemicolectomy, and histopathology revealed concurrent moderately differentiated mucinous adenocarcinoma arising within a high-grade appendiceal mucinous neoplasm-the first such case documented in the literature. This case underscores the need for early detection, proper surgery, and long-term follow-up in managing rare concurrent appendiceal tumors.
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http://dx.doi.org/10.1093/jscr/rjaf666 | DOI Listing |
Am J Surg
August 2025
Division of Surgical Oncology and Endocrine Surgery, Mayo Clinic, Arizona, 5777 E. Mayo Blvd. Phoenix, AZ, 85054, USA. Electronic address:
Background: Signet Ring Cell Adenocarcinoma (SRCA) of the appendix is a rare tumor with a poor prognosis and limited information to help guide treatment.
Methods: We reviewed patients diagnosed with SRCA between 1998 and 2024 at all Mayo Clinic sites.
Results: Among 84 patients, the most common presentation was non-specific abdominal pain (31 %).
World J Clin Oncol
August 2025
Division of Gastroenterologic Surgery, Department of Surgery, Tohoku Medical and Pharmaceutical University, Sendai 983-8536, Miyagi, Japan.
Appendiceal mucinous neoplasms (AMNs) are rare tumors originating from mucin-producing epithelial cells of the appendix. They can exhibit both benign and malignant behavior. They are often incidentally discovered during appendectomy.
View Article and Find Full Text PDFJ Surg Case Rep
August 2025
Department of Surgery, Prince Mohammed bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia.
Appendiceal neoplasms (ANs) are rare and often mimic acute appendicitis, complicating timely diagnosis. We report a unique case of a 57-year-old male presenting with right lower quadrant pain, found on imaging to have a ruptured appendiceal mucocele. He underwent open right hemicolectomy, and histopathology revealed concurrent moderately differentiated mucinous adenocarcinoma arising within a high-grade appendiceal mucinous neoplasm-the first such case documented in the literature.
View Article and Find Full Text PDFAnn Surg
August 2025
Department of Surgery, City of Hope National Medical Center, Duarte, CA.
Objective: Determine whether staged right colectomy for appendiceal cancer (initial appendectomy followed by completion colectomy - SRC) is detrimental to oncologic outcomes compared to upfront right colectomy (URC).
Background: The decision to perform right hemicolectomy for appendiceal cancer depends on histologic features of the primary tumor. SRC allows for histologic assessment of primary tumor and may avoid an unnecessary right colectomy if not indicated.
Front Oncol
July 2025
Department of Myxoma, Aerospace Center Hospital, Beijing, China.
Objective: To analyze the clinical efficacy of hysterectomy and bilateral salpingo-oophorectomy (BSO) in female patients with pseudomyxoma peritonei (PMP) of an appendiceal origin as well as to identify the prognostic factors associated with overall survival (OS) to reduce adverse physical or psychological effects on women.
Methods: A retrospective analysis was conducted to evaluate the prognostic factors in female patients with PMP of an appendiceal origin who underwent cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) including BSO at our hospital between January 2011 and December 2020. Patients were also divided into high and low grade group according to pathology subtype.