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Fractures of the trapezium occur infrequently, accounting for only 3.5 % of all carpal fractures. Trapezium fractures with concomitant Bennett's fracture-dislocations are exceedingly rare without a consensus on treatment recommendations. Here, we present a case of a simultaneous Bennett's fracture with a trapezium fracture in a pediatric patient. Our patient was treated with open reduction and internal fixation. Clinically, the patient was pain free with range of motion comparable to his uninjured side and without joint instability. A review of the literature reveals only twelve other cases reported in adult patients all of which were male with an average age of twenty-eight at the time of injury. Open reduction is the most popular treatment approach, but closed reduction can also be utilized with success in these injuries. While there is a large degree of heterogeneity of outcome reporting methodology, most patients have satisfactory outcomes and return to function comparable to their contralateral side.
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http://dx.doi.org/10.1016/j.jpra.2025.07.003 | DOI Listing |
JPRAS Open
September 2025
Division of Plastic Surgery, Michigan State University, Corewell Health, 275 Michigan Street NE, Grand Rapids, MI, 49503, USA.
Fractures of the trapezium occur infrequently, accounting for only 3.5 % of all carpal fractures. Trapezium fractures with concomitant Bennett's fracture-dislocations are exceedingly rare without a consensus on treatment recommendations.
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July 2025
Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Background: Sodium-glucose co-transporter 2 inhibitors (SGLT2i) slow progression of chronic kidney disease (CKD) but there is no randomised evidence of their effects on health-related quality of life (QoL) and healthcare use. We explored the effects of empagliflozin on health-related QoL, healthcare use and UK healthcare costs in the EMPA-KIDNEY trial.
Methods: EMPA-KIDNEY, a randomised, double blind, placebo-controlled, phase 3 trial, was conducted at 241 centres in eight countries (Canada, China, Germany, Italy, Japan, Malaysia, the UK, and the USA), and included participants aged 18 years or older with an estimated glomerular filtration rate (eGFR) of 20 to <45 mL/min/1.
bioRxiv
June 2025
Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Uveal melanoma (UM) is a highly aggressive intraocular malignancy with limited therapeutic options for metastatic disease. Existing transgenic UM mouse models inadequately recapitulate human disease progression, while transplant models lack immune competence for studying the tumor immune microenvironment and therapeutic interventions. To address these limitations, we developed a genetically engineered mouse model incorporating stepwise genetic alterations implicated in human UM progression.
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July 2025
Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-chōme-1-1 Ogawahigashichō, Kodaira, Tokyo, 187-8551, Japan.
Satralizumab showed a comparable safety profile versus placebo in 2 pivotal neuromyelitis optica spectrum disorder (NMOSD) studies. We analyzed infection rates with long-term satralizumab treatment in the open-label study, SAkuraMoon, and in a post-marketing setting (PMS), comparing frequencies with US-based health claims real-world data (US-RWD). Incidence rates of infection per 100 patient-years (IR/100 PY) were analyzed in the SAkura studies (clinical cut-off date: 31 January 2023).
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