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Background: Timely identification of mild cognitive impairment (MCI) is critical for maximizing early intervention opportunities in older adults at risk for dementia. This study evaluated the feasibility, acceptability, and validity of novel digital cognitive tests in primary care.
Methods: In a 16-month, two-phase pilot study across three clinics, 51 older adults completed digital cognitive assessments remotely on personal devices followed by supervised tablet-based cognitive screening in-clinic and the Montreal Cognitive Assessment (MoCA). Surveys and interviews assessed patient and provider acceptability. Digital test completion rates were examined to assess feasibility.
Results: Completion rates ranged from 60% - 76% for the at-home assessments and 81.8% for in-clinic testing. Participants generally preferred at-home testing. Providers found in-clinic testing acceptable but identified barriers related to device access and EMR integration. All but one digital test showed moderate correlations with the MoCA.
Conclusion: Digital cognitive screening-whether remote or in-clinic-shows promise for primary care implementation.
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http://dx.doi.org/10.1101/2025.08.19.25333983 | DOI Listing |
J Nephrol
September 2025
Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, Health Psychology Section, King's College London, 5th Floor Bermondsey Wing, Guy's Campus, London Bridge, London, SE1 9RT, UK.
Background: Depression and anxiety are common in chronic kidney disease (CKD) and worsen clinical outcomes. Psycho-behavioural interventions offer a promising, non-pharmacological approach. However, most evidence comes from people with kidney failure with distinct treatment needs, limiting relevance to earlier stages of CKD, where timely support may enhance self-management and slow progression.
View Article and Find Full Text PDFAlzheimers Dement
September 2025
Alzheimer's Disease Convergence Research Center, Samsung Medical Center, Seoul, South Korea.
Introduction: We developed and validated age-related amyloid beta (Aβ) positron emission tomography (PET) trajectories using a statistical model in cognitively unimpaired (CU) individuals.
Methods: We analyzed 849 CU Korean and 521 CU non-Hispanic White (NHW) participants after propensity score matching. Aβ PET trajectories were modeled using the generalized additive model for location, scale, and shape (GAMLSS) based on baseline data and validated with longitudinal data.
Front Psychol
August 2025
Department of Educational Psychology and Pedagogy, Faculty of Psychology, Lomonosov Moscow State University, Moscow, Russia.
Family socioeconomic status is broadly acknowledged to be associated with child development and wellbeing. However, the extent of this association across various dimensions of child development remains a topic of ongoing debate. This study aims to investigate the relationship between parental education and child cognitive and socioemotional skills, as well as the mediating role of children's leisure time activities, including screen time and shared book reading.
View Article and Find Full Text PDFGlob Ment Health (Camb)
July 2025
School of Social Sciences, College of Humanities, Arts, and Social Sciences, Nanyang Technological University, Singapore.
The global prevalence of mental health disorders among youths aged 15 to 24 is a significant public health concern. This systematic review aimed to explore global strategies for promoting mental well-being and addressing mental health challenges within this demographic, as defined by the World Health Organization. A comprehensive search of electronic scientific databases was conducted on November 1, 2023, yielding 43 studies with a total of 29,581 participants published between 2008 and 2023 that examined mental health interventions targeting youth.
View Article and Find Full Text PDFClin Epigenetics
September 2025
Department of Psychiatry and Psychotherapy, Philipps University Marburg, Marburg, Germany.
Background: Work-related stress is a well-established contributor to mental health decline, particularly in the context of burnout, a state of prolonged exhaustion. Epigenetic clocks, which estimate biological age based on DNA methylation (DNAm) patterns, have been proposed as potential biomarkers of chronic stress and its impact on biological aging and health. However, their role in mediating the relationship between work-related stress, physiological stress markers, and burnout remains unclear.
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