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A CRISPR Cas protein coronated AuNP nanostructure for enhanced uptake efficiency into cells. | LitMetric

A CRISPR Cas protein coronated AuNP nanostructure for enhanced uptake efficiency into cells.

Chem Commun (Camb)

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Published: September 2025


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Article Abstract

The effectiveness of nanotechnologies is often limited by their non-specific aggregation in biological environments. We developed a protein coronated nanostructure by functionalizing AuNPs with nucleic acid scaffolds and CRISPR Cas proteins, significantly enhancing nanoparticle stability and cellular uptake efficiency, making it a promising tool for imaging and biomedical applications.

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Source
http://dx.doi.org/10.1039/d5cc03658eDOI Listing

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