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Article Abstract
Purpose: To compare the outcomes between mastectomy (MAST) and breast-conserving surgery (BCS) in patients with metastatic breast cancer (dnMBC).
Methods: Patients diagnosed with dnMBC between 2010 and 2020 were retrospectively included. The chi-square test, binomial logistic regression, propensity score matching (PSM), Kaplan-Meier method, and multivariate Cox proportional analysis were used for statistical analyses.
Results: A total of 7880 patients were identified, including 2248 (28.5%) patients who underwent BCS and 5632 (71.5%) had achieved MAST. Although no statistically significant difference was found ( = 0.182), patients receiving MAST had a decreasing trend in later years. There were 74.3% ( = 629) of patients receiving MAST in 2010 and 68.5% ( = 366) in 2020. Younger age, advanced tumor stage, and advanced nodal stage were independent predictors of receiving MAST. There were 466 pairs of patients who were completely matched using PSM. The 3-year breast cancer-specific survival (BCSS) was 72.4% and 73.0% in patients treated with BCS and MAST, respectively ( = 0.509). The 3-year overall survival (OS) was 68.4% and 70.5% in patients treated with BCS and MAST, respectively ( = 0.702). The multivariate prognostic analyses showed that MAST had a similar BCSS ( = 0.996) and OS ( = 0.784) than those in BCS group.
Conclusions: Our study suggests that BCS and MAST yield similar survival outcomes in dnMBC.
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| http://dx.doi.org/10.1080/08941939.2025.2550774 | DOI Listing |
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