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Worldwide, cancer is one of the leading causes of death in humans. Interobserver variability and specialized experience are key factors in diagnosing gastrointestinal tract (GIT) abnormalities using endoscopic procedures. Due to this diversity, small lesions may go unnoticed, leading to a delay in early diagnosis. Therefore, it is essential to design a computer-aided diagnosis (CAD) system for the detection and classification of GIT diseases at the early stages. This paper proposes a CAD system that combines the feature fusion of modified deep learning models with optimal feature selection. Three publicly available datasets, including Kvasir V1, Kvasir V2, and Hyperkvasir, are utilized in the experimental process. In the proposed method, a contrast enhancement step is performed using the fusion of the top-bottom filtering technique. In the next step, two deep learning models (ResNet18 and ResNet50) are modified with a new layer called entropic field propagation (EFP). The pooling layers are replaced with EFP layers in both models, which are then trained on the selected datasets. In the testing process, trained models are employed, and features are extracted from the deeper layers, which are further refined using the Newton-Raphson Marine Predator Optimization (NRMPO) algorithm. The selected features from both models are finally fused using a novel mean threshold-based fusion approach and passed to machine learning classifiers. The proposed CAD system achieved accuracies of 99.0, 89.6, and 82.7% for Kvasir V1, Kvasir V2, and HyperKvasir, respectively. A detailed ablation study is also conducted for the middle steps that validate these reported accuracies. Conclusion: A comparison is performed with state-of-the-art (SOTA) techniques, showing that the proposed method achieves improved accuracy and precision rates.
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http://dx.doi.org/10.1038/s41598-025-17204-w | DOI Listing |
Hum Brain Mapp
September 2025
Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.
Postoperative aphasia (POA) is a common complication in patients undergoing surgery for language-eloquent lesions. This study aimed to enhance the prediction of POA by leveraging preoperative navigated transcranial magnetic stimulation (nTMS) language mapping and diffusion tensor imaging (DTI)-based tractography, incorporating deep learning (DL) algorithms. One hundred patients with left-hemispheric lesions were retrospectively enrolled (43 developed postoperative aphasia, as the POA group; 57 did not, as the non-aphasia (NA) group).
View Article and Find Full Text PDFJ Chem Theory Comput
September 2025
Dipartimento di Chimica, Università di Pavia, Via Taramelli 12, Pavia 27100, Italy.
Machine learning (ML) and deep learning (DL) methodologies have significantly advanced drug discovery and design in several aspects. Additionally, the integration of structure-based data has proven to successfully support and improve the models' predictions. Indeed, we previously demonstrated that combining molecular dynamics (MD)-derived descriptors with ML models allows to effectively classify kinase ligands as allosteric or orthosteric.
View Article and Find Full Text PDFACS Sens
September 2025
Institute of Applied Mechanics, National Taiwan University, Taipei 106, Taiwan.
In recent AI-driven disease diagnosis, the success of models has depended mainly on extensive data sets and advanced algorithms. However, creating traditional data sets for rare or emerging diseases presents significant challenges. To address this issue, this study introduces a direct-self-attention Wasserstein generative adversarial network (DSAWGAN) designed to improve diagnostic capabilities in infectious diseases with limited data availability.
View Article and Find Full Text PDFMagn Reson Med
September 2025
Centre for Integrative Neuroimaging, FMRIB Division, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Purpose: To develop a deep learning-based reconstruction method for highly accelerated 3D time-of-flight MRA (TOF-MRA) that achieves high-quality reconstruction with robust generalization using extremely limited acquired raw data, addressing the challenge of time-consuming acquisition of high-resolution, whole-head angiograms.
Methods: A novel few-shot learning-based reconstruction framework is proposed, featuring a 3D variational network specifically designed for 3D TOF-MRA that is pre-trained on simulated complex-valued, multi-coil raw k-space datasets synthesized from diverse open-source magnitude images and fine-tuned using only two single-slab experimentally acquired datasets. The proposed approach was evaluated against existing methods on acquired retrospectively undersampled in vivo k-space data from five healthy volunteers and on prospectively undersampled data from two additional subjects.
Behav Res Methods
September 2025
Czech Technical University in Prague, Faculty of Electrical Engineering, Department of Cybernetics, Prague, Czech Republic.
Automatic markerless estimation of infant posture and motion from ordinary videos carries great potential for movement studies "in the wild", facilitating understanding of motor development and massively increasing the chances of early diagnosis of disorders. There has been a rapid development of human pose estimation methods in computer vision, thanks to advances in deep learning and machine learning. However, these methods are trained on datasets that feature adults in different contexts.
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