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Article Abstract
A diastereoselective Pd-catalyzed allylic C-F bond functionalization of pentafluoroethyl alkenes is described. Heteroatom nucleophiles including amines, alcohols, and thiols can be employed to construct new C-N, C-O, or C-S bonds with concomitant cleavage of an allylic C-F bond. Both 1,1- and 1,2-disubstituted pentafluoroalkenes can be utilized to synthesize novel tetra- and trisubstituted alkenes containing an sp-carbon connected to both F and CF in good to excellent diastereoselectivities.
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| http://dx.doi.org/10.1021/acs.orglett.5c03217 | DOI Listing |
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