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Article Abstract
Monounsaturated fatty acids (MUFAs), particularly palmitoleic, oleic and nervonic acids, serve essential functions in cardiovascular health, metabolic regulation and neuroprotection. Microbial fermentation has emerged as a sustainable production platform that circumvents the geographical constraints and high costs associated with traditional agricultural systems. This review establishes a holistic framework for sustainable MUFA production, systematically integrating upstream metabolic engineering (Δ9 desaturase pathway optimization and chassis strain design), midstream precision fermentation (artificial intelligence-driven dynamic control of bioreactor parameters), and downstream processing (supercritical fluid extraction and microencapsulation). Key strategies include enhancing precursor flux via enzyme engineering, resolving NADPH cofactor imbalances, implementing artificial intelligence-guided genome-scale metabolic models for real-time bioprocess optimization. This review emphasizes the value of microbial production of MUFAs and its optimization methods, while exploring its potential in nutraceutical and biomedical applications.
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| http://dx.doi.org/10.1016/j.fm.2025.104894 | DOI Listing |
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