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Disseminated mycobacterium colombiense infection associated with anti-interferon-γ autoantibody: a case report and literature review. | LitMetric

Disseminated mycobacterium colombiense infection associated with anti-interferon-γ autoantibody: a case report and literature review.

Diagn Microbiol Infect Dis

Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 61004l, China. Electronic address:

Published: August 2025


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Article Abstract

A 46-year-old male presented with multifocal osteolytic lesions and rash. mNGS of clavicular biopsy identified M.colombiense, confirmed by culture and MALDI-TOF MS. Initial improvement with clarithromycin-based therapy was followed by relapse post-trauma, coinciding with anti-interferon-γ autoantibody detection and new-onset diabetes. Despite negative follow-up cultures, imaging and clinical response supported reactivation.

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Source
http://dx.doi.org/10.1016/j.diagmicrobio.2025.117087DOI Listing

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