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Background: Brainstem cavernous malformations (BSCMs) are rare vascular lesions, most frequently located in the pons. Their surgical management is particularly demanding due to the dense concentration within the brainstem of eloquent neural pathways and nuclei. Among various surgical routes, the endoscopic endonasal transclival approach (EETA) has been established as a valuable option for treating selected ventrally located lesions.
Observations: The authors report the case of a 54-year-old woman with a ventral pontine cavernous malformation (CM) presenting with recurrent hemorrhagic episodes, all resolving without neurological sequelae. Based on the anterior midline location of the lesion within the pons and the posterolateral displacement of the corticospinal tracts (CSTs) on preoperative tractography, an EETA was deemed the most suitable approach. Gross-total removal was achieved without neurological worsening or postoperative CSF leakage.
Lessons: This case supports the use of EETA as a safe and effective surgical route for ventral pontine CMs with anterior surface presentation. Accurate preoperative planning, including assessment of CST displacement via diffusion tensor imaging, and direct intraoperative cortical stimualtion are essential for identifying a safe entry point. Although technically demanding and not universally applicable, EETA offers a direct surgical corridor that minimizes neurovascular manipulation and facilitates favorable outcomes in selected cases. https://thejns.org/doi/10.3171/CASE25356.
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http://dx.doi.org/10.3171/CASE25356 | DOI Listing |
J Neurosurg Case Lessons
September 2025
Department of Neurosciences and Reproductive and Odontostomatological Sciences, Division of Neurosurgery, University of Napoli "Federico II," Naples, Italy.
Background: Brainstem cavernous malformations (BSCMs) are rare vascular lesions, most frequently located in the pons. Their surgical management is particularly demanding due to the dense concentration within the brainstem of eloquent neural pathways and nuclei. Among various surgical routes, the endoscopic endonasal transclival approach (EETA) has been established as a valuable option for treating selected ventrally located lesions.
View Article and Find Full Text PDFEntropy (Basel)
August 2025
Department of Imaging Neuroscience, UCL Queen Square Institute of Neurology, London WC1N 3AR, UK.
The organization of consciousness is described through increasingly rich theoretical models. We review evidence that working memory capacity-essential to generating consciousness in the cerebral cortex-is supported by dual limbic memory systems. These dorsal (Papez) and ventral (Yakovlev) limbic networks provide the basis for mnemonic processing and prediction in the dorsal and ventral divisions of the human neocortex.
View Article and Find Full Text PDFJ Comp Neurol
August 2025
Kresge Hearing Research Institute, Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.
A ventral tectal longitudinal column (TLCv) has been described in rats and is hypothesized to provide multisensory modulation of acoustic processing in the superior olivary complex. The TLCv is a column of cells in the dorsomedial tectum extending rostro-caudally through the inferior and superior colliculi. It receives ascending auditory input and projects to the superior olivary complex.
View Article and Find Full Text PDFOper Neurosurg
August 2025
Department of Neurosurgery, Yeditepe University School of Medicine, Istanbul, Turkey.
Brain Struct Funct
August 2025
Faculty of Medicine and Health, The University of New South Wales, Sydney, NSW, 2052, Australia.
The retrotrapezoid nucleus (RTN) of rodents is located ventral to the facial motor nucleus (7N) and consists of acid-sensitive neurons that activate breathing and mediate the central component of the ventilatory response to hypercapnia. In rodents, RTN neurons can be histologically identified by the presence of paired-like homeobox 2B positive nuclei (Phox2b +) and the absence of cytoplasmic choline acetyltransferase (ChAT-) and tyrosine hydroxylase (TH-). Up to 50% of rodent RTN neurons synthesise galanin, and 88% express pituitary adenylate cyclase activating polypeptide (PACAP).
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