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http://dx.doi.org/10.1056/NEJMp2503525 | DOI Listing |
Nat Med
September 2025
Prilenia Therapeutics B.V., Naarden, the Netherlands.
Huntington's disease (HD) is a rare, neurodegenerative disorder for which only symptomatic treatments are available. The PROOF-HD study was a randomized, double-blind, placebo-controlled phase 3 trial evaluating the efficacy and safety of pridopidine, a selective Sigma-1 receptor agonist, in HD. The primary and key secondary endpoints, change in total functional capacity (TFC) and composite Unified Huntington's Disease Rating Scale (cUHDRS) score at week 65, were not met in the overall population.
View Article and Find Full Text PDFNatl Med J India
August 2025
Department of Community Medicine, ESIC Medical College and Hospital, Chennai, Tamil Nadu, India.
Background Medical research is the backbone of advances in medical technology. To decrease the deficit in the physician- scientist ratio in developing countries, initiatives are being taken to inspire medical students to pursue research careers. Hence, it is necessary to understand the attitudes of undergraduate (UG) medical students towards medical research.
View Article and Find Full Text PDFJAMA Ophthalmol
August 2025
Population, Policy and Practice Department, University College London, Great Ormond Street Institute of Child Health, London, United Kingdom.
Importance: Anterior-segment optical coherence tomography (AS-OCT) has broad clinical and research utility. The utility of quantitative data derived from AS-OCT is, however, dependent on the quality and consistency of the cumulative evidence base.
Objective: To develop consensus-based nomenclature that supports standardized reporting of AS-OCT image acquisition and analyses as a foundation to improve research reproducibility.
Am J Obstet Gynecol
July 2025
Department of Obstetrics and Gynecology, University of Virginia School of Medicine, Charlottesville, VA.