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An electrochemical method for carbazole synthesis dehydrogenative aryl-aryl coupling of arylamines under metal-free conditions at ambient temperature is presented. The reactivity of arylamines is rationalised by cyclic voltammetry and density functional theory (DFT) studies to provide a preliminary understanding of the observed regioselectivity.
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http://dx.doi.org/10.1039/d5cc03841c | DOI Listing |
ACS Omega
September 2025
Department of Chemistry, Faculty of Science, Dokuz Eylul University, Izmir 35160, Turkey.
A novel silica-based sorbent, silica-carbazole-formazan (Si-Carb-Formazan), was synthesized through in situ functionalization with a newly prepared carbazole formazan derivative to remove Cu-(II) ions from aqueous solutions efficiently. The sorbent was characterized using techniques such as FTIR, SEM, TGA, and XPS, which revealed a porous structure with a high surface area and excellent thermal stability. Batch adsorption experiments analyzed the influence of various factors on the sorbent's performance, demonstrating its high efficiency.
View Article and Find Full Text PDFBioorg Chem
September 2025
Department of Medicinal Chemistry, Shandong Key Laboratory of Druggability Optimization and Evaluation for Lead Compounds, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, PR China. Electronic address:
A series of novel 3,3-dimethyl-2,3,4,9-tetrahydro-1H-carbazole derivatives were rationally designed, synthesized and evaluated for their biological activity as AcrB inhibitors. The compounds were assessed for their antibiotic potentiating effects, followed by evaluation of Nile Red efflux inhibition, and off-target effects including activity on the outer and inner bacterial membranes. Ten compounds potentiated antibiotic activity at sub-inhibitory concentrations, reducing the minimum inhibitory concentrations (MICs) of at least one of the tested antibiotics by at least 8-fold, with three derivatives (7c, 11g, and 11i) achieving 32-fold MIC reductions at 128 μg/mL.
View Article and Find Full Text PDFMini Rev Med Chem
September 2025
Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur, 247341, India.
The growing prevalence of multidrug resistance and its detrimental effects pose a significant threat to public health, which is one reason for the current interest in the introduction of novel agents. To combat this adverse effect and drug resistance, numerous drugs have been developed over time, and their safety is still being evaluated; derivatives or medications based on the carbazole moiety are one of the key contributors. Therefore, this review explores carbazole-based derivatives as possible drugs to treat Alzheimer's, diabetes, inflammation, cancer, and many more, along with their synthetic schemes, SARs, and activity.
View Article and Find Full Text PDFChem Commun (Camb)
September 2025
Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), 1 Pesek Road, Singapore 627833, Republic of Singapore.
An electrochemical method for carbazole synthesis dehydrogenative aryl-aryl coupling of arylamines under metal-free conditions at ambient temperature is presented. The reactivity of arylamines is rationalised by cyclic voltammetry and density functional theory (DFT) studies to provide a preliminary understanding of the observed regioselectivity.
View Article and Find Full Text PDFJ Manag Care Spec Pharm
September 2025
Division of Medical Oncology, Department of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles.
Background: Alectinib, brigatinib, and lorlatinib are all preferred first-line (1L) therapies for anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) in National Comprehensive Cancer Network (NCCN) guidelines. Although clinical trials have demonstrated their efficacy, real-world evidence on treatment patterns, costs, and outcomes may help differentiate these therapies and inform optimal 1L treatment selection in the absence of head-to-head comparisons.
Objective: To evaluate real-world outcomes for patients with ALK+ NSCLC receiving 1L ALK tyrosine kinase inhibitors (TKIs), focusing on drug acquisition costs, health care utilization, and clinical outcomes.