Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Since their introduction to the beef industry, genotyping technologies have opened the door for genomic selection and accelerated population improvement. Single nucleotide polymorphism (SNP) arrays have served as the backbone of genomic selection programs since their introduction. Developments in sequencing and genotype imputation offer alternatives to array-based genotyping that have the potential to provide orders of magnitude more information at a lower cost. In this review, I give an overview of array-based genotyping, genomic sequencing, and low-pass sequencing & imputation. Additionally, I provide perspectives on how low-coverage sequencing and imputation could simultaneously drive genomic discovery and be used for routine genotyping as sequencing costs continue to decline.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/jas/skaf293 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Identification of known and novel genetic variants in sensorineural hearing loss: insights from whole exome sequencing in Indian families.
Mol Biol Rep
September 2025
Cytogenetics and Molecular Genetics Lab, Pathology Unit, Medical Division (BARC Hospital), Bhabha Atomic Research Centre, Anushakti Nagar, Mumbai, India.
Background: Hearing loss (HL) is one of the most common congenital anomalies and is a complex etiologically diverse condition. Molecular genetic characterization of HL remains challenging owing to the high genetic heterogeneity. This study aimed to screen for potential disease-causing genetic variations in a cohort of Indian patients with congenital bilateral severe-to-profound sensorineural HL.
View Article and Find Full Text PDFEnhanced metagenomic surveillance for bovine respiratory disease pathogens and antimicrobial resistance by hybridization capture sequencing.
Appl Environ Microbiol
September 2025
Department of Biology, University of Regina, Regina, Saskatchewan, Canada.
Unlabelled: Bovine respiratory disease (BRD) is the primary disease of cattle and is responsible for most of the antibiotic use in the beef industry, both for metaphylaxis and treatment. Infection prevention and targeted treatments would benefit from detecting and identifying bacterial pathogens and, ideally, assessing antibiotic sensitivity. Here, we report success refining targeted metagenomics by hybridization capture sequencing (CapSeq) to detect and genotype bacterial pathogens and genes for antibiotic resistance in BRD.
View Article and Find Full Text PDFA novel missense single-nucleotide polymorphism (c.149G>A) in the bovine gene and its association with growth traits in Madura cattle.
Vet World
July 2025
Research Center for Applied Zoology, National Research and Innovation Agency, Republic of Indonesia, Bogor, Indonesia.
Background And Aim: The () gene plays a pivotal role in regulating growth, metabolism, and fat deposition in cattle. Genetic polymorphisms in this gene can influence phenotypic traits and may serve as molecular markers for selection in breeding programs. However, comprehensive characterization of gene variants in local Indonesian breeds, such as Madura cattle, remains limited.
View Article and Find Full Text PDFAn integrative pan-cancer analysis of USP37 and functional validation in pancreatic cancer.
Front Cell Dev Biol
August 2025
Department of Hepatobiliary Surgery, The First Hospital of Putian City, Chengxiang, Fujian, China.
Background: USP37, a versatile deubiquitinase, plays a pivotal role in numerous cellular functions. Although its involvement in cancer development is well-established, the comprehensive pan-cancer analysis of USP37 remains relatively uncharted.
Methods: RNA sequencing data from both normal and cancerous tissues were retrieved from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases.
Association Between DRD4 rs747302 and VNTR Polymorphisms and Drug Addiction in An Iraqi Population.
Cell Physiol Biochem
September 2025
Zoology Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Background/aims: Drug addiction is a neuropsychiatric disorder characterised by compulsive drug-seeking behaviour notwithstanding adverse consequences. This work seeks to address a deficiency in the literature by comparing drug-addicted and non-addicted individuals within an Iraqi population through the analysis of a 1000-base pair variable number of tandem repeats (VNTRs) polymorphism of the dopamine receptor gene DRD4. The association of this novel polymorphism with drug addiction has not yet been examined.
View Article and Find Full Text PDF