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Background: Internalizing symptoms are highly prevalent in childhood and adolescence. Several studies have demonstrated heterogeneity in symptom trajectories and examined their predictors. However, little is known about their outcomes in late adolescence. Building on a previous study that identified a stable low, an increasing and an (early high) decreasing trajectory of internalizing symptoms in childhood, this follow-up study examines their outcomes, including mental health-related measures and self-regulation facets.
Methods: Trajectories of internalizing symptoms were identified using parent reports at three measurement points in a community sample of N = 1453 children aged 6-13 years, based on the Emotional Problems Scale of the Strengths and Difficulties Questionnaire. At the 8-year follow-up, n = 556 adolescents aged 16-21 years participated, providing self-reports on mental health-related measures and self-regulation facets (emotional reactivity, emotion regulation, planning behavior, risk taking, impulsiveness, delay discounting). Additionally, three self-regulation facets (working memory updating, inhibition, risk taking) were assessed behaviorally.
Results: Adolescents in the increasing trajectory reported significantly greater internalizing symptoms, more specific anxiety symptoms, greater distress and social impairment, and more impaired personality functioning than those in the stable low trajectory, and more specific depressive symptoms than those in the stable low and decreasing trajectories. Regarding SR facets, they reported lower planning behavior and less use of the emotion regulation strategies reappraisal and positive reappraisal than those in the stable low trajectory, and greater use of the emotion regulation strategy catastrophizing than those in the stable low and decreasing trajectories.
Conclusions: Children with increasing internalizing symptoms in childhood present internalizing symptoms and self-regulation deficits in late adolescence that can hinder further development. In contrast, the differences observed in childhood between the decreasing and the stable low trajectories are no longer detectable. Promoting self-regulation could be a promising prevention and intervention target. Future research should investigate protective factors contributing to symptom remission.
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http://dx.doi.org/10.1186/s13034-025-00958-6 | DOI Listing |
Prog Neuropsychopharmacol Biol Psychiatry
September 2025
Department of Women's and Children's Health, SciLifeLab, Uppsala University, Sweden. Electronic address:
Estrogens are suggested to affect mood by binding to widespread estrogen receptors in the brain and therewith modulating a variety of neurosignaling pathways. Single nucleotide polymorphisms (SNPs) in the genes encoding estrogen receptors might influence these actions and thereby play a role in the genetic foundation of mood disorders. Several SNPs in the estrogen receptor 1 (ESR1) gene have been studied in relation to anxiety and depression, while confounders and interaction with psychosocial factors have largely been overlooked.
View Article and Find Full Text PDFPsychiatry Res
September 2025
Department of Clinical Sciences, Psychiatry, Lund University, Sölvegatan 19 - BMC I12, 221 84 Lund, Sweden. Electronic address:
Negative consequences of gambling problems have primarily been examined in terms of symptoms and impairment, with less focus on well-being, a key indicator of intra- and interpersonal functioning and a critical outcome in treatment. Additionally, the role of co-occurring psychopathology in this relation remains unclear. This study examined the relation between gambling problems and well-being in a large population-based sample of individuals who gamble (N = 1005; 52.
View Article and Find Full Text PDFJ Affect Disord
September 2025
Department of Public Health, Bartholins Allé 2, Aarhus University, 8000, Aarhus C, Denmark. Electronic address:
Purpose: To study the association between internalizing and externalizing symptoms and prosocial behavior at age 7 years and pubertal timing in boys and girls.
Methods: This cohort study included 11,090 children from the Puberty Cohort within the Danish National Birth Cohort (DNBC). Data on internalizing and externalizing symptoms and prosocial behavior was derived from a parent-reported Strengths and Difficulties Questionnaire (SDQ) at age 7 years, and categorized as normal (lowest 79th percent), at-risk (80th - 89th percent) or abnormal (≥90th percent).
Pediatr Allergy Immunol
September 2025
Food Allergy Referral Centre, Veneto Region, Department of Women and Child Health, Padua University Hospital, Padua, Italy.
This narrative review aimed to explore mental health issues among children with food-induced anaphylaxis (FIA) and their parents and to identify possible risk factors. A review of the scientific literature from 2005 to 2025 (MEDLINE, PubMed, PsycINFO) was done, and 31 papers were selected. Results were presented according to DSM-V diagnostic categories.
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