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Introduction And Aims: Fractal dimension (FD) and lacunarity are increasingly applied to assess trabecular bone structure, yet their predictive value for early dental implant failure remains uncertain. This study investigated whether FD and lacunarity, measured on panoramic radiographs and cone-beam computed tomography (CBCT), can predict early implant loss in the mandible.
Methods: A retrospective case-control study included 48 patients-24 with early implant failure and 24 with implants surviving at least 5 years without periimplantitis. All had panoramic radiographs, and a subset of 30 patients (15 per group) also had CBCT scans. FD and lacunarity were assessed in 3 mandibular regions: frontal, premolar, and molar. ImageJ software with box-counting method was used. FD from panoramic images was calculated using the White and Rudolph method; CBCT-based FD values were derived using both the White and Rudolph and the Kato et al. methods.
Results: No significant differences in FD or lacunarity values were found between groups in any region on either imaging modality (P > .05).
Conclusions: Fractal dimension and lacunarity values obtained from panoramic radiographs and CBCT images did not demonstrate predictive capability for early implant failure. Although fractal analysis offers a non-invasive approach to assess trabecular bone architecture, it should not be used in isolation to estimate implant prognosis.
Clinical Relevance: While fractal analysis may provide complementary insights into bone microstructure, its standalone application lacks sufficient reliability for predicting early dental implant failure. Future studies involving larger cohorts are warranted.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12414887 | PMC |
http://dx.doi.org/10.1016/j.identj.2025.103880 | DOI Listing |
Angiogenesis
September 2025
Division of Plastic Surgery, Department of Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, 17033, USA.
Vascularization of implanted biomaterials is critical to reconstructive surgery and tissue engineering. Ultimately, the goal is to promote a rapidly perfusable hierarchical microvasculature that persists with time and can meet underlying tissue needs. We have previously shown that using a microsurgical technique, termed micropuncture (MP), in combination with porous granular hydrogel scaffolds (GHS) fabricated via interlinking hydrogel microparticles (microgels) results in a rapidly perfusable patterned microvasculature.
View Article and Find Full Text PDFAim To compare the results of primary percutaneous coronary intervention (PCI) for non-ST-segment elevation acute coronary syndrome (NSTE-ACS) in patients who recently recovered from COVID-19 with those not previously infected with SARS-CoV-2; to establish prognostic criteria for PCI complications, including stent thrombosis and restenosis (ST and SR) and progression of ischemic heart disease, and to determine ways to prevent them.Material and methods In 2021, middle-aged patients admitted to the Baku Central Clinical Hospital with a diagnosis of acute coronary syndrome who underwent urgent myocardial revascularization using percutaneous balloon angioplasty of the occluded coronary artery (CA) with implantation of a second-generation intracoronary drug-eluting stent were divided into two observation groups: the main group of 123 patients who had COVID-19 in the previous 6 months, and the control group of 112 patients who were not previously infected with SARS-CoV-2. The immediate results of PCI were assessed according to the TIMI scale; complications were assessed both clinically, by the incidence of severe complications (major adverse cardiovascular events, MACE), and angiographically, by the incidence of early and late ST and SR, and de novo stenosis that developed during the two-year observation period.
View Article and Find Full Text PDFEur Heart J Case Rep
September 2025
Feinberg School of Medicine, Northwestern University, 303E Chicago Ave, Ward 1-003, Chicago, IL 60611, USA.
Background: Cardiac laminopathies, associated with mutations in the LMNA gene, are a rare inherited disorder characterized by a broad range of clinical manifestations. There are currently no data on the association between supraventricular re-entrant tachycardias and LMNA-related cardiomyopathy.
Case Summary: A 26-year-old male presented with either wide-QRS tachycardia with a left bundle branch block (LBBB) pattern or narrow QRS tachycardia, as well as a history of palpitations since age 15.
Periodontol 2000
September 2025
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
Transcrestal sinus augmentation has emerged as a minimally invasive alternative to lateral window techniques for vertical bone augmentation in the edentulous maxilla. Since its early introduction and modification over the last several decades, this technique has demonstrated predictable outcomes for implant placement in regions with limited bone height. This narrative review examines the current understanding and evolution of transcrestal sinus floor elevation (TSFE), focusing on factors related to long-term stability.
View Article and Find Full Text PDFSci Rep
September 2025
Laboratory of Animal Morphology, Department of Animal Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, 464-8601, Aichi, Japan.
During early pregnancy in mice, leukemia inhibitory factor (LIF) regulates embryo implantation by activating the JAK/STAT3 signaling pathway. The STAT3 pathway has been recognized to play a critical role in embryo implantation; however, it remains unclear whether STAT3 activation alone is sufficient to induce implantation. In this study, we investigated the effects of RO8191, a potential STAT3 activator, on embryo implantation through a series of studies with different mouse models.
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