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Achieving sustainable agriculture requires balancing high productivity with minimal environmental impact, a challenge that is ongoing for both farmers and policymakers. This study proposes an innovative approach by integrating life cycle assessment (LCA), data envelopment analysis (DEA), causal loop diagrams (CLD), and the DPSIR (Driving forces, Pressures, State, Impacts, Responses) framework to evaluating regenerative agriculture systems (RAS) in Central Europe. Focusing on wheat and maize production in Slovakia, we assessed scenarios involving different herbicides containing glyphosate and pyridine compounds, as well as the use of cow manure. LCA was first applied to quantify the environmental impacts of each scenario. These results were then used along with the crop yield data in DEA to assess environmental efficiency in the various scenarios, taking into account both environmental and economic goals. CLD and DPSIR frameworks were employed to support a systems-level interpretation of the findings. The LCA results indicated that the complete removal of two key herbicides (Scenario 4) for durum wheat and maize production led to the lowest environmental impact but also the lowest yield. In contrast, applying two key herbicides slightly increased environmental impacts but resulted in higher yields. DEA results indicate that Scenario 1, which incorporates two key herbicides, was the most environmentally efficient for durum wheat, while both Scenarios 1 and 3, which include one key herbicide, were effective for maize. Overall, while the environmental burden differences between scenarios were relatively small, the differences in crop yields were substantial. Therefore, scenarios involving at least one key herbicide proved the most environmentally and economically optimal.
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http://dx.doi.org/10.1016/j.scitotenv.2025.180360 | DOI Listing |
J Trace Elem Med Biol
September 2025
Department of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, Kraków 31-343, Poland. Electronic address:
Vanadium (V) is a trace element in the environment; it is detected in soil, water, air, dust, and food products. V-containing compounds have shown therapeutic potential in the treatment of diabetes. However, studies on the effects of V on animal behavior remain limited and sporadic.
View Article and Find Full Text PDFJ Trace Elem Med Biol
September 2025
Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China. Electronic address:
Objective: We previously documented that exposure to a spectrum of elements is associated with autism spectrum disorder (ASD). However, there is a lack of mechanistic understanding as to how elemental mixtures contribute to the ASD development.
Materials And Methods: Serum and urinary concentrations of 26 elements and six biomarkers of ASD-relevant pathophysiologic pathways including serum HIPK 2, serum p53 protein, urine malondialdehyde (MDA), urine 8-OHdG, serum melatonin, and urine carnitine, were measured in 21 ASD cases and 21 age-matched healthy controls of children aged 6-12 years.
Int J Epidemiol
August 2025
Department of Biostatistics and Informatics, University of Colorado, Aurora, CO, United States.
Background: Existing longitudinal cohort study data and associated biospecimen libraries provide abundant opportunities to efficiently examine new hypotheses through retrospective specimen testing. Outcome-dependent sampling (ODS) methods offer a powerful alternative to random sampling when testing all available specimens is not feasible or biospecimen preservation is desired. For repeated binary outcomes, a common ODS approach is to extend the case-control framework to the longitudinal setting.
View Article and Find Full Text PDFJMIR Cancer
September 2025
iCARE Secure Data Environment & Digital Collaboration Space, NIHR Imperial Biomedical Research Centre, London, United Kingdom.
Background: Electronic health records (EHRs) are a cornerstone of modern health care delivery, but their current configuration often fragments information across systems, impeding timely and effective clinical decision-making. In gynecological oncology, where care involves complex, multidisciplinary coordination, these limitations can significantly impact the quality and efficiency of patient management. Few studies have examined how EHR systems support clinical decision-making from the perspective of end users.
View Article and Find Full Text PDFJMIR Form Res
September 2025
Department of Emergency Medicine, College of Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Background: Hospital falls represent a persistent and significant threat to safety within health care systems worldwide, impacting both patient well-being and the occupational health of health care staff. While patient falls are a primary concern, addressing fall risks for all individuals within the health care environment remains a key objective. Caregiver visibility and spatial monitoring are recognized as crucial considerations in mitigating fall-related incidents.
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