98%
921
2 minutes
20
The rise of biomedical foundation models creates new hurdles in model testing and authorization, given their broad capabilities and susceptibility to complex distribution shifts. We suggest tailoring robustness tests according to task-dependent priorities and propose to integrate granular notions of robustness in a predefined specification to guide implementation. Our approach facilitates the standardization of robustness assessments in the model lifecycle and connects abstract AI regulatory frameworks with concrete testing procedures.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397224 | PMC |
http://dx.doi.org/10.1038/s41746-025-01926-2 | DOI Listing |
ISA Trans
September 2025
School of Astronautics, Harbin Institute of Technology, Harbin, China. Electronic address:
For space missions such as extraterrestrial sample collection, robotic rover exploration, and astronaut landings, the complex terrain and diverse gravitational environments make ground-based micro-low-gravity experimental systems essential for testing and validating spacecraft performance as well as supporting astronaut training. The suspended gravity unloading (SGO) system is a key device commonly used to simulate micro-low-gravity environments. However, the SGO system faces challenges due to model uncertainty and external disturbances, which limit improvements in control accuracy.
View Article and Find Full Text PDFMed Eng Phys
October 2025
College of Basic Medical Science, Shanxi University of Chinese Medicine, Jinzhong, 030619, Shanxi, China.
Pulse diagnosis holds a pivotal role in traditional Chinese medicine (TCM) diagnostics, with pulse characteristics serving as one of the critical bases for its assessment. Accurate classification of these pulse pattern is paramount for the objectification of TCM. This study proposes an enhanced SMOTE approach to achieve data augmentation, followed by multi-domain feature extraction.
View Article and Find Full Text PDFInt J Toxicol
September 2025
RTI International, Washington, DC, USA.
Technological advances and the desire to reduce dependence on animal models have brought human-relevant models to the forefront of drug development. This paradigm shift is leveraging the advances in systems and new approach methodologies (NAMs), which was the focus of a workshop convened by the Health and Environmental Sciences Institute (HESI) in May 2024. Highlights included discussions on predicting cardiac failure modes and the utility of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), microfluidic systems like BioFlux™, and engineered heart tissues in enhancing early-stage drug safety assessments.
View Article and Find Full Text PDFBioinspir Biomim
September 2025
Mechanical Intelligence (MI) Research Group, London South Bank University, 103 Borough Road, London, London, SE1 0AA, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
Conventional rigid grippers remain the most-used robotic grippers in industrial assembly tasks. However, they are limited in their ability to handle a diverse range of objects. This study draws inspiration from nature to address these limitations, employing multidisciplinary methods, such as computer-aided design, parametric modeling, finite element analysis, 3D printing, and mechanical testing.
View Article and Find Full Text PDFChem Biodivers
September 2025
Department of Clinical Pharmacy, College of Pharmacy, University of Sulaimani, Sulaimani, Iraq.
The global rise in antibiotic resistance demands the urgent development of new antibacterial agents. This study investigated the antibacterial potential of four synthesized methoxy and thiophene chalcone derivatives (designated 3a, 4a, 3b, and 4b) against clinically relevant bacterial pathogens. These compounds were prepared through Claisen-Schmidt condensation, while their chemical structures were verified through applying Fourier-transform infrared, mass spectrometry, H nuclear magnetic resonance (NMR), and C NMR.
View Article and Find Full Text PDF