Longitudinal profiling of the human gut microbiome reveals temporal and personalized responses to inulin.

IMetaOmics

CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

Published: June 2025


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Article Abstract

This study monitored gut microbiome changes in healthy volunteers following inulin intervention, revealing dynamic and highly individualized shifts in microbial composition and short-chain fatty acid production. Using batch cultures, correlation analysis, and predictive modeling, we explored the personalized microbiome response. Our findings highlight the individualized response of the gut microbiome to prebiotics and the need for precision nutrition.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379954PMC
http://dx.doi.org/10.1002/imo2.70029DOI Listing

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