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This review evaluates anterior, posterior, and combined fixation techniques for pediatric odontoid fractures, addressing the lack of comparative data on outcomes and complications. A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-based review identified 1,497 studies, with eight meeting inclusion criteria after screening. Studies were assessed for quality using the Joanna Briggs Institute checklist, and data on demographics, fracture types, surgical techniques, fusion rates, and complications were analyzed. Among 62 pediatric cases, posterior approaches were the most common (66.1%), followed by anterior approaches (27.4%) and combined approaches (6.5%). Fusion rates were highest with combined approaches (100%), followed by the posterior approach (92.7%) and the anterior approach (88.2%). However, the posterior approach had the highest complication rate (43.9%), including infections, persistent symptoms, and failed fusion. Combined approaches demonstrated superior outcomes with no complications, whereas anterior techniques, although effective in select cases, resulted in one mortality. This review highlights the superior outcomes of combined approaches for complex pediatric odontoid fractures, achieving 100% fusion with no complications. Posterior techniques remain reliable, but advancements in technique and postoperative care are necessary to reduce complications further. High-quality, multicenter studies are crucial for establishing standardized management protocols and evaluating long-term outcomes.
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http://dx.doi.org/10.7759/cureus.88866 | DOI Listing |
Eur J Radiol
September 2025
Department of Radiology, Affiliated Hospital of Hebei University, Baoding 071000, China. Electronic address:
Purpose: The present study aimed to develop a noninvasive predictive framework that integrates clinical data, conventional radiomics, habitat imaging, and deep learning for the preoperative stratification of MGMT gene promoter methylation in glioma.
Materials And Methods: This retrospective study included 410 patients from the University of California, San Francisco, USA, and 102 patients from our hospital. Seven models were constructed using preoperative contrast-enhanced T1-weighted MRI with gadobenate dimeglumine as the contrast agent.
JMIR Cancer
September 2025
iCARE Secure Data Environment & Digital Collaboration Space, NIHR Imperial Biomedical Research Centre, London, United Kingdom.
Background: Electronic health records (EHRs) are a cornerstone of modern health care delivery, but their current configuration often fragments information across systems, impeding timely and effective clinical decision-making. In gynecological oncology, where care involves complex, multidisciplinary coordination, these limitations can significantly impact the quality and efficiency of patient management. Few studies have examined how EHR systems support clinical decision-making from the perspective of end users.
View Article and Find Full Text PDFNeuro Endocrinol Lett
September 2025
Faculty of Science, Jan Evangelista Purkyně University, Ústí nad Labem, Czech Republic.
Objective: In addition to hypogonadism, other endocrine disorders-particularly hyperprolactinemia-can significantly influence erectile dysfunction (ED) in men. The aim of our study was to evaluate the effect of normalizing prolactin (PRL) levels on erectile function in men diagnosed with ED and hyperprolactinemia. The primary outcome was improvement in IIEF-5.
View Article and Find Full Text PDFJ Org Chem
September 2025
A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky St, Irkutsk 664033, Russian Federation.
In this work, the superbase-mediated self-organization of tetrasubstituted pyrroles from three molecules of acetylenes and one molecule of nitriles was theoretically investigated. On the example of interaction of phenylacetylene with benzonitrile in the KOBu/DMSO medium, three possible pathways of the assembly of 2-benzyl-3,5-diphenyl-4-phenylethynyl-1-pyrrole have been studied using a combined B2PLYP-D3/6-311+G**//B3LYP-D3/6-31+G* quantum chemical approach. The calculated activation barriers correspond to mild reaction conditions (room temperature for 15 min).
View Article and Find Full Text PDFJMIR Cancer
September 2025
Cancer Patients Europe, Rue de l'Industrie 24, Brussels, 1000, Belgium.
Background: Breast cancer is the most common cancer among women and a leading cause of mortality in Europe. Early detection through screening reduces mortality, yet participation in mammography-based programs remains suboptimal due to discomfort, radiation exposure, and accessibility issues. Thermography, particularly when driven by artificial intelligence (AI), is being explored as a noninvasive, radiation-free alternative.
View Article and Find Full Text PDF