98%
921
2 minutes
20
Background: Although exposure therapy is a proven treatment for post-traumatic stress disorder (PTSD), empirical research is difficult due to ethical issues. Recently, virtual reality-based content that can provide space and time similar to reality for exposure therapy techniques is increasing.
Aim: To examine exposure therapy using driving simulations in patients with PTSD due to traffic accidents with PTSD symptoms.
Methods: The intervention was provided to two individuals who experienced PTSD symptoms after a traffic accident using a driving simulator. Among the single-subject experimental designs, the ABA (baseline-intervention-baseline) design was used, and the PTSD checklist and brain wave frequency were used to measure the results.
Results: In all participants, the standard category departure time of the electroencephalogram decreased from baseline, and PTSD symptoms decreased after the intervention.
Conclusion: These results suggest the potential use of a driving simulator as an exposure treatment tool for PTSD.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336977 | PMC |
http://dx.doi.org/10.12998/wjcc.v13.i26.100363 | DOI Listing |
Phys Chem Chem Phys
September 2025
Department of Physics, Indian Institute of Technology Jodhpur, N.H. 62, Nagaur Road, Karwar, Jodhpur, Rajasthan, 342030, India.
We report an anomalous temperature-induced transition in thermal conductivity in the germanene monolayer around a critical temperature = 350 K. Equilibrium molecular dynamics simulations reveal a transition from ∼ scaling below the to ∼ above, contrasting with conventional ∼ behavior. This anomalous scaling correlates with the long-scale characteristic timescale obtained from double exponential fitting of the heat current autocorrelation function.
View Article and Find Full Text PDFChem Biol Drug Des
September 2025
Laboratory of Biochemistry and Animal Toxins, Institute of Biotechnology, Federal University of Uberlandia, Uberlandia, MG, Brazil.
Leishmaniasis, a disease caused by Leishmania parasites, poses a significant health threat globally, particularly in Latin America and Brazil. Leishmania amazonensis is an important species because it is associated with both cutaneous leishmaniasis and an atypical visceral form. Current treatments are hindered by toxicity, resistance, and high cost, driving the need for new therapeutic targets and drugs.
View Article and Find Full Text PDFChem Biol Interact
September 2025
Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address:
Prolyl endopeptidase (PREP) drives neurodegenerative diseases through dual mechanisms involving enzymatic activity and protein-protein interactions (PPIs), yet current inhibitors predominantly target single pathways Prolyl endopeptidase (PREP) fuels neurodegeneration via enzymatic cleavage and pathological PPIs, yet current inhibitors usually target only one facet. In this study, leveraging our developed high-sensitivity and high-specificity near-infrared fluorescent probe Z-GP-ACM, we established and validated a screening platform for PREP inhibitors with mouse brain S9 instead of the human recombinant PREP. Screening a library of 110 natural compounds identified a series of flavonoid derivatives (FV64-FV68) as potent PREP inhibitors, with FV67 and FV68 exhibiting particularly strong inhibition (IC values of 0.
View Article and Find Full Text PDFJ Electromyogr Kinesiol
September 2025
Biomedical Engineering Program (COPPE), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Evidence on regional muscle excitation within hamstrings remains controversial, primarily because information derived solely from surface electromyograms (sEMG) amplitude does not necessarily provide an accurate estimate of neural drive to the muscle. To address this limitation, this study investigated whether there are proximodistal differences in motor unit properties of the biceps femoris long head during isometric hip extension and knee flexion tasks. Seventeen resistance-trained males performed isometric knee flexion and hip extension tasks at 20 % and 40 % of maximal voluntary contraction.
View Article and Find Full Text PDFDrug Discov Today
September 2025
Department of Pharmaceutical and Artificial-Intelligence Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Key Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Peptide & Protein Drug Research Cen
The landscape of allosteric drug discovery is undergoing a transformative shift, driven by the integration of three computational approaches: machine learning (ML), molecular dynamics (MD) simulations, and network theory. ML identifies potential allosteric sites from multidimensional biological datasets; MD simulations, empowered by enhanced sampling algorithms, reveal transient conformational states; and network analyses uncover communication pathways, further aiding in site identification. Their synergy enables rational allosteric modulator design.
View Article and Find Full Text PDF