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Objective: To clinically validate manual measurement of cochlear length from pre-operative image of cochlea with post-operative image of cochlear implant (CI) electrode.
Methods: Temporal bone computer tomography (CT) scans of 23 ears were available for this pilot study. The inner ear was three-dimensionally (3D) segmented, and cochlea length was manually measured for preferred angular depth depending on inner ear anatomical types for CI electrode length selection. Post-operative CT scans were made available for electrode reconstruction to measure electrode length inside the cochlea to validate pre-operative measurement of cochlear length.
Results: Normal anatomy (NA) inner ear was identified in 11 ears, enlarged vestibular aqueduct syndrome (EVAS) in 4 ears, incomplete partition (IP) type I in 2 ears, cochlear hypoplasia (CH) in 5 ears, and otosclerosis in 1 ear. Cochlear length was measured for 650° of angular depth in NA ears, 540° in EVAS and otosclerosis, 360° in IP type I, and for available angular depth depending on the development of the cochlea in CH type. Based on the cochlea length measured, a closely matching electrode length was chosen for implantation from 1 CI manufacturer. Partial insertion was seen in 2 NA ears, 1 otosclerosis ear, and 1 CH ear, whereas full insertion of the chosen electrode was achieved in the remaining 19 ears.
Conclusion: Manual measurement of cochlea length from 3D image of cochlea is a practical way of choosing electrode length for preferred angular insertion depth depending on the cochlea anatomy.
Level Of Evidence: Between level 2 and 3.
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http://dx.doi.org/10.1002/lio2.70237 | DOI Listing |
Laryngoscope Investig Otolaryngol
August 2025
Objective: To clinically validate manual measurement of cochlear length from pre-operative image of cochlea with post-operative image of cochlear implant (CI) electrode.
Methods: Temporal bone computer tomography (CT) scans of 23 ears were available for this pilot study. The inner ear was three-dimensionally (3D) segmented, and cochlea length was manually measured for preferred angular depth depending on inner ear anatomical types for CI electrode length selection.
Hum Genet
August 2025
Centro de Pesquisa Sobre o Genoma Humano e Células-Tronco (HUG- CELL), Departamento de Genética e Biologia Evolutiva, Instituto de Biociências IBUSP, Universidade de São Paulo, São Paulo, SP, 05508-090, Brazil.
Connexin 26, the protein encoded by the GJB2 (Gap junction protein beta 2) gene, is expressed in different tissues, including the cochlea and skin. Pathogenic DNA alterations in GJB2 cause autosomal recessive nonsyndromic hearing loss, whereas some GJB2 variants may lead to deafness-associated skin disorders. Genes encoding proteins of the Connexin26 molecular complex may fit as candidates to explain genetic hearing loss of yet unknown etiology.
View Article and Find Full Text PDFHear Res
August 2025
Dept. of Otolaryngology, Harvard Medical School, Boston, MA, United States; Eaton-Peabody Laboratories, Massachusetts Eye & Ear, Boston, MA, United States; Graduate Program in Speech and Hearing Bioscience and Technology, Harvard University, Cambridge, MA, United States. Electronic address: sunil_pu
The micromechanics of the cochlear organ of Corti (OoC) are crucial for hearing, yet they remain poorly understood. This study explores a proposed finite-element (FE) modeling approach aimed at capturing the three-dimensional (3D) motion of the OoC under the influence of the traveling wave. This technique uses a thin slice of the cochlea, making computation feasible while preserving the intricate details of its structures.
View Article and Find Full Text PDFJ Laryngol Otol
August 2025
Department of Ophthalmology, All India Institute of Medical Sciences, Rishikesh, India.
Objectives: To compare two high-resolution computerised tomography based pre-surgical planning software in measuring the cochlear dimensions, which can aid in designing/choosing customised cochlear implant electrodes.
Methods: A cross-sectional-observational study was conducted in a tertiary care centre using high-resolution computerised tomography-supported software Otoplan and curved multi-planar reconstruction to find cochlear duct length's maximum and minimum width/diameter and height in 110 ears (55 subjects). Measurements and the time taken by both techniques were compared.
Dev Biol
July 2025
USC Caruso Department of Otolaryngology - Head and Neck Surgery, Keck School of Medicine of University of Southern California, USA; Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of University of Southern California, USA. Electronic address:
Hearing loss is the most prevalent type of sensory deficit in humans. Recent studies have found adeno-associated viruses (AAVs) targeting hair cells as promising vectors for inner ear gene therapy. However, targeting non-sensory cell types, which are often affected by genetic mutations causing sensorineural hearing loss, remains a challenge.
View Article and Find Full Text PDF