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The global energy market faces significant challenges due to increasing demand, growing competition, and the ongoing shift toward renewable sources. Addressing these complexities requires advanced methodologies that can effectively navigate uncertainty and optimize investment and operational decisions. This study presents a flexible scenario-based framework for capacity-related decision making and investment planning in energy systems comprising solar, wind, and natural gas facilities. The proposed framework integrates Bayesian Neural Networks (BNNs) into an optimization problem to address uncertainties in energy generation and demand forecasts. By leveraging posterior distributions from BNNs, the framework generates probabilistic, data-driven scenarios that capture future uncertainties. These scenarios are incorporated into a two-stage stochastic multi-period mixed-integer linear optimization model. The first stage optimizes investment decisions for new facilities prior to the realization of uncertainty, while the second stage incorporates operational costs, capacity expansions, and penalties for unmet demand across multiple future scenarios and time periods. We present a case study in Texas, demonstrating the applicability of the proposed framework. The results indicate the details on the capacity expansion and investment strategies for natural gas, wind and solar power plants to meet the increasing energy demand in the state. The model accounts for real-world considerations such as construction and expansion lag times, capacity constraints, and scenario-dependent demands. This methodology enhances the flexibility of energy systems, enabling planners to make cost-effective future investments and operational decisions through the complexities of the modern energy landscape. The proposed framework offers significant advantages over traditional methods by capturing nuanced uncertainty distributions and enabling flexible decision-making.
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http://dx.doi.org/10.1016/j.compchemeng.2025.109097 | DOI Listing |
Mikrochim Acta
September 2025
Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Salmonella Typhimurium (S. Typhimurium) is one of the most common food-borne diseases, highlighted as the top food-borne bacterial pathogen in the world with a low infectious dose (1 CFU) and high mortality rate. It is commonly associated with numerous foods such as dairy products, protein sources (multiple types of meat, poultry, and eggs), and bakery products.
View Article and Find Full Text PDFInd Health
September 2025
Ministry of Employment and Labor, Republic of Korea.
Research on worker exposure to volatile organic compounds (VOCs) during asphalt paving operations remains significantly limited, and regulatory frameworks governing such exposures are also insufficient. Previous studies have primarily focused on a limited number of major VOCs. However, this study employs high-resolution, high-performance Proton Transfer Reaction Time-of-Flight Mass Spectrometry (PTR-ToF-MS) to comprehensively evaluate exposure levels to 25 different VOCs.
View Article and Find Full Text PDFJ Am Acad Psychiatry Law
September 2025
Dr. Dernbach is a medical toxicologist and current addiction psychiatry fellow, Department of Psychiatry, Harvard Medical School, Boston, MA. Dr. Appel is a Professor of Psychiatry and Medical Education, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY.
Clinicians face the prospect of mandated reporting when a patient reports, either during the intake appointment or during the course of addiction treatment, their risky substance use-related behavior around a child. Beyond legal considerations, many factors might influence a clinician's decision whether or not to report the case to child protective services (CPS). Although there is literature regarding mandated reporting in the setting of pre- or perinatal substance use, there is limited literature regarding the mandated reporting obligation in the setting of postnatal substance use around children.
View Article and Find Full Text PDFLab Anim
September 2025
Research Support Office, Faculty of Veterinary Medicine, Utrecht University, the Netherlands.
Animals used in science and education should be used by competent laboratory animal science (LAS) staff, both for reasons of reproducibility and to safeguard animal welfare. In this article, we propose entrustable professional activities (EPAs) as a structure to support and assess development of competence and valid entrustment decisions of persons working with laboratory animals in practice following, or in combination with, basic training. We propose the creation of a consensus framework and provide concepts that would encourage harmonisation in competence-based development.
View Article and Find Full Text PDFJ Med Ethics
September 2025
Shrewsbury Public Schools, Shrewsbury, Massachusetts, USA
The integration of artificial intelligence (AI) into pharmaceutical practices raises critical ethical concerns, including algorithmic bias, data commodification and global health inequities. While existing AI ethics frameworks emphasise transparency and fairness, they often overlook structural vulnerabilities tied to race, gender and socioeconomic status. This paper introduces relational accountability-a feminist ethics framework-to critique AI-driven pharmaceutical practices, arguing that corporate reliance on biased algorithms exacerbates inequalities by design.
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