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Article Abstract

Background: Acute colonic pseudo-obstruction (ACPO) is defined as colonic obstruction without a mechanical or extrinsic inflammatory factor. Colonic decompression is advised for patients with ACPO after the failure of conservative and medical management.

Aim: To systematically review and analyze the efficacy and safety of colonoscopic decompression in ACPO.

Methods: A search was conducted in MEDLINE, EMBASE, and Scopus from inception to August 2024. Studies reporting the clinical success, perforation, recurrence, and need for surgery after colonoscopic decompression in ACPO were included. A random-effects inverse-variance model was used to calculate the pooled proportion.

Results: Sixteen studies were included in the final analysis. The pooled rates of success after the first session of colonoscopic decompression and overall success were 78.8% (95%CI: 72.0-85.6) and 91.5% (95%CI: 87.0-96.0), respectively. The first session of colonoscopic decompression had a significantly higher success than the first dose of neostigmine with OR 3.85 (95%CI: 2.00-7.42). The pooled incidence of perforation was 0.9% (95%CI: 0.0-2.0), while recurrence was observed in 17.1% (95%CI: 12.9-21.3) of the patients after clinical success. The pooled rates of surgery in all cases undergoing colonoscopic decompression and those who had a successful procedure were 10.5% (95%CI: 5.0-15.9) and 3.7% (95%CI: 0.3-7.1), respectively. Subgroup analysis, excluding the low-quality studies, did not significantly change the event rates.

Conclusion: Colonoscopic decompression for ACPO is associated with a clinical success rate of > 90% with a perforation rate of < 1%, demonstrating high efficacy and safety.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304928PMC
http://dx.doi.org/10.5492/wjccm.v14.i3.102733DOI Listing

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Background: Acute colonic pseudo-obstruction (ACPO) is defined as colonic obstruction without a mechanical or extrinsic inflammatory factor. Colonic decompression is advised for patients with ACPO after the failure of conservative and medical management.

Aim: To systematically review and analyze the efficacy and safety of colonoscopic decompression in ACPO.

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Introduction: Acute colonic pseudo-obstruction is an uncommon but not infrequent encounter among hospitalized patients. The American Society for Gastrointestinal Endoscopy recommended neostigmine first before colonoscopy; however, the Association of Coloproctology of Great Britain and Ireland consensus guidelines in emergency colorectal surgery acknowledge the lack of evidence in the superiority of one approach over the other. This is the first meta-analysis aimed to fill this gap of evidence by including studies comparing neostigmine and colonoscopy in resolving the pseudo-obstruction.

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Article Synopsis
  • Ogilvie syndrome is a rare condition marked by acute colonic dilation, first described in 1948, with an incidence of about 100 cases per 100,000 people annually in the US, and major symptoms include abdominal distention and pain.
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