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http://dx.doi.org/10.1007/s11033-025-10950-0 | DOI Listing |
J Med Internet Res
September 2025
Department of Information Systems and Cybersecurity, The University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX, 78249, United States, 1 (210) 458-6300.
Background: Adverse drug reactions (ADR) present significant challenges in health care, where early prevention is vital for effective treatment and patient safety. Traditional supervised learning methods struggle to address heterogeneous health care data due to their unstructured nature, regulatory constraints, and restricted access to sensitive personal identifiable information.
Objective: This review aims to explore the potential of federated learning (FL) combined with natural language processing and large language models (LLMs) to enhance ADR prediction.
Chem Biodivers
September 2025
Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala, Punjab, India.
Argemone mexicana is one of the known herbaceous plants hosting bioactive isoquinoline alkaloids. In the current study, an endophytic fungal isolate was studied for anti-inflammatory potential and the identification of its bioactive molecule. An endophytic fungus AMEF-14 was obtained from this plant and identified as Cladosporium ramotenellum based on microscopy and molecular tools.
View Article and Find Full Text PDFPlast Reconstr Surg
August 2025
Professor of Surgery, Section of Plastic Surgery, Department of Surgery, Michigan Medicine, Ann Arbor, MI.
The use of pragmatic clinical trials has been increasing within medical and surgical research departments but has not yet been widely implemented in plastic surgery. Pragmatic clinical trials (PCTs) are similar to randomized controlled trials (RCTs) in that they both randomize patients to treatments and follow them prospectively after treatment. However, pragmatic trials are less strict than RCTs in many ways: PCTs have fewer inclusion and exclusion criteria to facilitate the recruitment of representative samples, PCTs collect data during routine clinical care, and they commonly rely on subjective patient-reported outcomes.
View Article and Find Full Text PDFInt J Audiol
September 2025
Department of Otolaryngology-Head & Neck Surgery, University of California San Francisco, San Francisco, California, USA.
Objective: To develop and pilot test a combined-learning intervention for Tanzanian primary healthcare workers on ear and hearing care (EHC), comprising five self-led smartphone-based modules and in-person workshops.
Design: The intervention was piloted with primary healthcare workers in Tanzania. Pre- and post-training surveys assessed knowledge, confidence, and attitudes towards EHC via Likert scales.
PLoS One
September 2025
Department of Zoology, Baba Guru Nanak University, Nankana Sahib, Pakistan.
Secreted frizzled-related protein 4 (sFRP4) plays a fundamental role in the regulation of Wnt signalling, which is crucial for cellular proliferation and differentiation. The sFRP4 has garnered significant interest as a therapeutic target for metabolic diseases and cancer due to its mechanism of action. Although existing sFRP4 modulators show limited specificity and notable off-target effects, our study explores the potential of known bioactive compounds as more selective and less toxic alternatives.
View Article and Find Full Text PDF