Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Intravenous thrombolysis is the most widely available effective ischemic stroke treatment, but is approved only if given within 4.5 h from stroke onset. Many patients are not treated because stroke onset time is unknown. We evaluated the cytokine interleukin 6 (IL-6) in circulating blood after acute ischemic stroke (AIS). Results show IL-6 is elevated as early as 26 min after stroke and increases over 24 h. The IL-6 levels can estimate when the stroke occurred with 80% sensitivity and 74% specificity. With refinement, a point-of-care blood test for IL-6 during stroke could substantially increase the number of stroke patients eligible for thrombolysis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/acn3.70138 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Longitudinal imaging evaluation of the inflammatory role of purinergic AA receptors during subacute and chronic ischemic stroke.
J Cereb Blood Flow Metab
September 2025
Achucarro Basque Center for Neuroscience, Leioa, Spain.
Adenosine A receptors (AARs) have shown promising therapeutic properties despite their controversial role in modulating stroke outcome. However, the temporal evolution of cerebral AARs density after cerebral ischemia and its subsequent neuroinflammatory response have been scarcely explored. In this study, the expression of AARs after transient middle cerebral artery occlusion (MCAO) was evaluated in rats by positron emission tomography (PET) with [C]SCH442416 and immunohistochemistry (IHC).
View Article and Find Full Text PDFFunctional Connectivity of Hippocampal Circuits and Visual Memory Function in Children and Adolescents With Perinatal Stroke.
Hum Brain Mapp
September 2025
Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Perinatal stroke is a vascular injury occurring early in life, often resulting in motor deficits (hemiplegic cerebral palsy/HCP). Comorbidities may also include poor neuropsychological outcomes, such as deficits in memory. Previous studies have used resting state functional MRI (fMRI) to demonstrate that functional connectivity (FC) within hippocampal circuits is associated with memory function in typically developing controls (TDC) and in adults after stroke, but this is unexplored in perinatal stroke.
View Article and Find Full Text PDFTrimethylamine N-oxide (TMAO) for risk stratification after acute ischemic stroke: Results from the BIOSIGNAL cohort study.
Eur Stroke J
September 2025
Department of Neurology & Stroke Center, University Hospital of Basel & University of Basel, Basel, Switzerland.
Introduction: Recent studies in stroke patients from predominantly Asian populations have underscored the significance of trimethylamine N-oxide (TMAO) as a valuable blood biomarker for predicting incident strokes and major adverse cardiovascular events (MACE). However, its prognostic role after ischemic stroke in other populations is not yet comprehensively investigated.
Patients And Methods: We measured plasma TMAO levels in 1726 acute ischemic stroke patients (within 24 h from symptom onset) from the multicenter BIOSIGNAL cohort.
Decisional Conflict of Proxies in the Thrombolysis Decision-Making Process for Acute Ischaemic Stroke Patients.
Int J Nurs Pract
October 2025
First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Background: Despite being efficacious for acute ischemic stroke, treatment with thrombolysis is often delayed because of the inaccessibility of informed consent from patient proxies. Decisional conflict could be an important contributor to this delay; however, its influencing factors remain unknown. This study sought to survey the decisional conflict of proxies for sufferers of acute ischaemic stroke and explore the influencing factors.
View Article and Find Full Text PDFThe GPR120 agonist TUG-891 mitigates ischemic brain injury by attenuating endoplasmic reticulum stress and apoptosis via the PI3K/AKT signaling pathway.
Neurotherapeutics
September 2025
Department of Neurology, Peking University Third Hospital, Beijing, 100191, China; Beijing Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases, Beijing, 100191, China; Key Laboratory for Neuroscience, National Health Commission/Ministry of Education, Peking Universit
Extensive research has confirmed that omega-3 fatty acids provide cardiovascular protection primarily by activating the G protein-coupled receptor 120 (GPR120) signaling pathway. However, natural activators of this receptor often lack sufficient strength and precision. TUG-891, a recently synthesized selective GPR120 activator, has displayed significant therapeutic potential in multiple disease.
View Article and Find Full Text PDF