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The majority of patients receiving cancer chemotherapy are treated in the outpatient setting and require peripheral intravenous (IV) access. The purpose of this work was to evaluate for differences in infusion unit nurses' ratings of predictors of difficult intravenous access (DIVA) based on whether they cared for patients with solid tumours versus hematologic malignancies. Nurses (N=152) received an email with a link to a Qualtrics survey. Nurses completed the "Survey on Nurses" perceived DIVA factors that asked them to rate each factor using a 0 (not at all predictive) to 10 (extremely predictive) numeric rating scale. Compared to nurses who cared for patients with solid tumours, those who cared for patients with hematologic malignancies rated the following predictors higher: patient is overweight, patient has obesity, occurrence of psychomotor agitation, and occurrence of needle phobia or anxiety. Findings can be used to guide the education of infusion unit nurses on specific risk factors for DIVA.
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http://dx.doi.org/10.5737/23688076352321 | DOI Listing |
J Vis Exp
August 2025
Physiology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases.
Resistance arteries, which include small arteries and arterioles, play essential roles in regulating blood pressure and tissue perfusion. Dysfunction in these arteries can lead to various cardiovascular conditions such as hypertension, atherosclerosis, and heart failure, as well as neurovascular conditions. The examination of human resistance arteries is crucial for understanding cardiovascular disease mechanisms and developing targeted therapeutic strategies.
View Article and Find Full Text PDFCurr Drug Deliv
August 2025
Department of Pharmaceutics, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune 411018, India.
Introduction: Burn wounds are painful injuries that demand immediate and effective management. Conventional wound care solutions often have limitations, such as discomfort during application or removal and potential damage to healing tissue. Therefore, developing novel wound dressings that support biological processes and promote wound healing is highly beneficial.
View Article and Find Full Text PDFTurk J Anaesthesiol Reanim
September 2025
Ankara University Faculty of Medicine, Department of Anaesthesiology and Reanimation, Ankara, Türkiye.
Objective: Procedural sedation management in geriatric patients undergoing cystoscopy requires careful monitoring due to age-related physiological changes and increased sensitivity to anaesthetic agents. Although both target-controlled infusion (TCI) and conventional total intravenous anaesthesia (TIVA) techniques with propofol are commonly used methods for sedation, their comparative effectiveness and safety in this population remain subjects of ongoing investigation. This study aims to compare the effectiveness of the two techniques in terms of time to induction, recovery time, hemodynamic stability, airway intervention requirements, and propofol consumption.
View Article and Find Full Text PDFInt J Antimicrob Agents
September 2025
Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai, China; National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Fudan University, Shanghai, China. Electronic address:
Background: This study characterized the urinary pharmacokinetics and pharmacodynamics (PK/PD) of linezolid (LNZ) in critically ill patients with renal impairment and nosocomial multidrug-resistant Gram-positive urinary tract infections (UTIs). The aim was to address therapeutic challenges arising from limited treatment options and uncertain urinary excretion, to establish optimized dosing strategies.
Methods: A prospective observational study was conducted in ICU patients with renal impairment.
Farm Hosp
September 2025
Servicio de Farmacia, Hospital Universitario de Toledo, Toledo, Spain.
Objective: To standardize the drug dilutions administered intravenously in a Pediatric Intensive Care Unit and to characterize these dilutions based on their pH, osmolarity, and vesicant nature. This aims to guide the selection of the most appropriate vascular access device, minimizing associated complications, and preserving the patient's venous capital.
Methods: Through a consensus between Pharmacy and Pediatric Services, the most frequently administered intravenous drugs in the Pediatric Intensive Care Unit were selected.