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http://dx.doi.org/10.1080/07853890.2025.2551279 | DOI Listing |
Cardiol Young
September 2025
Department of Pharmacy, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA.
Introduction: Neonates with ductal-dependent CHD rely on the patency of the ductus arteriosus to maintain circulation. Alprostadil is utilised to maintain ductal patency, although optimal dosing has not been determined. This study aims to describe alprostadil dosing in neonates with ductal-dependent CHD.
View Article and Find Full Text PDFIntern Med
September 2025
Department of Gastroenterology and Hepatology, Toyota Kosei Hospital, Japan.
Agranulocytosis is an extremely rare but potentially fatal immune-related adverse event (irAE) induced by immune checkpoint inhibitors (ICIs). Its management, particularly following combination therapies such as durvalumab/tremelimumab (Dur/Tre) for hepatocellular carcinoma (HCC), is challenging owing to limited data. We herein report a 79-year-old man with HCC who developed severe Dur/Tre-induced agranulocytosis that was refractory to granulocyte colony-stimulating factor, high-dose corticosteroids, and intravenous immunoglobulin.
View Article and Find Full Text PDFBiomed Chromatogr
October 2025
College of Medicine, Lishui University, Lishui, China.
Saikosaponin A (SSa) is an oleanane type triterpenoid saponin isolated from Radix Bupleuri (Bupleurum chinense DC). While SSa has demonstrated significant pharmacological activities including anti-inflammatory, antioxidant, and antidepressant effects, its pharmacokinetic profile remains poorly characterized. This study developed and validated a sensitive LC-MS/MS method for quantifying SSa in rat plasma.
View Article and Find Full Text PDFRes Vet Sci
September 2025
Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand. Electronic address:
Carprofen (CAR) is an NSAID commonly used in veterinary medicine that preferentially inhibits cyclooxygenase-2 (COX-2), thereby mitigating inflammation and pain while minimizing adverse effects linked to cyclooxygenase-1 (COX-1) inhibition. This study characterizes the pharmacokinetics of CAR in Siamese crocodiles (Crocodylus siamensis) and was conducted at an ambient temperature range of 27-30 °C following single intravenous (IV) or intramuscular (IM) administration at 2 mg/kg, and IM administration at 4 mg/kg. Plasma concentrations were determined using a validated high-performance liquid chromatography method with ultraviolet detection (HPLC-UV).
View Article and Find Full Text PDFIntern Med J
September 2025
Lyell McEwin Hospital, Adelaide, South Australia, Australia.
Where possible, antimicrobials, such as clindamycin, should be given orally rather than intravenously when efficacy will be equivalent. A single-centre pre-/post-intervention study was conducted. There were 11 134 patients admitted to included wards during the study period.
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