Cerebrospinal Fluid Volume and Other Intracranial Volumes Are Associated with Fazekas Score in Adults: A Single Center Experience.

: The objective of this research is to make a comparative evaluation of the correlation between the volumetric examination of subcortical cerebral regions and white matter hyperintensities classified according to the Fazekas scoring system. : A total of 236 cases with cranial MRI studies were retrospectively analyzed. This study included patients aged over 45 years who had white matter hyperintensities and who did not have a prior stroke diagnosis. White matter hyperintensities were evaluated in axial FLAIR images according to Fazekas's grading scale. Patients with Fazekas 0 and 1 were grouped in group 1 and the patients with Fazekas 2 and 3 were grouped in group 2. MRI data processing and subcortical volumetric analyses were performed using the volBrain MRI brain volumetry system. : There were statistically significant differences between groups 1 and 2 in terms of cerebrospinal fluid total brain white and gray matter ( < 0.001), total brain white and gray matter ( = 0.009), total cerebrum ( < 0.001), accumbens ( < 0.001), thalamus ( < 0.001), frontal lobe ( < 0.001), parietal lobe ( < 0.001), and lateral ventricle ( < 0.001) volumes. : Our study finds a strong link between white matter hyperintensity burden and brain atrophy. This includes volume reductions in total brain white and gray matter, frontal and parietal lobe atrophy, increased cerebrospinal fluid (CSF), and atrophy in specific brain regions such as the accumbens and thalamus.