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To improve chip removal efficiency and drilling performance in oxygen-free copper, a multi-objective optimization of gun drilling process parameters was conducted using a response surface methodology and a genetic algorithm. The Box-Behnken Design (BBD) response surface analysis method was employed to evaluate the effects of feed rate, cutting speed, and cutting fluid pressure on the chip evacuation coefficient and chip volume ratio. Experimental results indicate that among the three factors, the feed rate has the most significant influence, followed by the cutting speed and the cutting fluid pressure. Additionally, the interaction between the cutting speed and the cutting fluid pressure notably impacts both chip evacuation and chip volume ratio. Using response surface modeling, a three-dimensional predictive model was developed. Based on this fitted model, optimal gun drilling parameters were identified through genetic algorithm optimization, minimizing the chip evacuation coefficient and chip volume ratio to achieve an optimized machining configuration. The optimal drilling parameters were identified as a feed rate of 0.019 mm/r, a spindle speed of 47.1 m/min, and a cutting fluid pressure of 2.4 MPa. Under these conditions, a chip evacuation coefficient of 3.2951 and a chip volume ratio of 3.3345 were achieved. The resulting chips predominantly exhibited a C-shaped morphology, accompanied by smooth and efficient evacuation.
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http://dx.doi.org/10.3390/ma18163913 | DOI Listing |
Nat Immunol
September 2025
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
CD4 T follicular helper (T) cells support tailored B cell responses against multiple classes of pathogens. To reveal how diverse T phenotypes are established, we profiled mouse T cells in response to viral, helminth and bacterial infection. We identified a core T signature that is distinct from CD4 T follicular regulatory and effector cells and identified pathogen-specific transcriptional modules that shape T function.
View Article and Find Full Text PDFPflugers Arch
September 2025
Department of Science, University "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.
Hypoxia has been extensively studied as a stressor which pushes human bodily systems to responses and adaptations. Nevertheless, a few evidence exist onto constituent trains of motor unit action potential, despite recent advancements which allow to decompose surface electromyographic signals. This study aimed to investigate motor unit properties from noninvasive approaches during maximal isometric exercise in normobaric hypoxia.
View Article and Find Full Text PDFJ Immunol
September 2025
Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Qidong-Fudan Innovative Institution of Medical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Hepatitis B virus (HBV) exclusively infects hepatocytes and produces large quantities of subviral particles containing its surface antigen (HBsAg). T cells play a central role in controlling HBV infection but can also mediate liver injury and contribute to disease progression. However, the mechanisms that regulate T-cell responses to eliminate the virus without causing immunopathology during acute HBV infection remain poorly defined.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Department of Chemical & Biochemical Engineering, Dongguk University, Seoul, 04620, Republic of Korea. Electronic address:
Modified hyaluronic acid (HA) biomaterials have received considerable attention in recent years, especially in developing innovative therapeutic strategies for targeted disease interventions. HA serves to shield therapeutics from the physiological environment, while enabling safe delivery and promoting uptake into specific cells. As a hydrophilic chain polymer, HA is readily chemically modified into functional biomaterials for drug delivery and cancer immunotherapy.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. Electronic address:
The thermosensitive transient receptor potential (Thermo-TRP) channel proteins comprise TRPA1, TRPV1-V4, and TRPM8. TRP channels are mainly situated on cellular surfaces and react to a range of external factors, including heat, cold, acidity, osmotic pressure, chemical signals, and flavors, as well as intracellular signals such as Ca, Na, and cytokines. The thermo-TRP channels are associated with many physiological signal pathways, with their distinct molecular structure making them promising drug targets for respiratory diseases.
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