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Turning-point memories, experiences that impact personal development, may be interpreted in ways that emphasize positive, negative, or mixed development because the memory prompt is open-ended with regard to event valence (i.e., it does not elicit 'high'-point or 'low'-point life events). Broadly, narratives that articulate how one has grown or changed for the better over time are positively associated with beneficial psychological characteristics and well-being, and are thought to be a cultural master narrative template in the United States (US). Recent work suggests cultural differences in the narration of adversity. Our mixed-methods study expands the literature on cultural comparisons of turning-point autobiographical memories by comparing themes in turning-point memory narratives of US and UK college-going emerging adults and by assessing whether or not narrative differences relate to changes in well-being and emotions after narration. Results suggest that turning points are characterized by memories of adversity and that redemptive narration is similar across samples in its frequency and associations with well-being and emotions. Discussion explores when and why redemptive narration may be beneficial for people from broad backgrounds.
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http://dx.doi.org/10.3390/bs15081127 | DOI Listing |
Behav Sci (Basel)
August 2025
Department of Psychological Sciences, Weber State University, Ogden, UT 84408, USA.
Turning-point memories, experiences that impact personal development, may be interpreted in ways that emphasize positive, negative, or mixed development because the memory prompt is open-ended with regard to event valence (i.e., it does not elicit 'high'-point or 'low'-point life events).
View Article and Find Full Text PDFPLoS One
August 2025
School of Engineering, Institute for Imaging, Data and Communications, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Modularity is a well-established concept for assessing community structures in various single and multi-layer networks, including those in biological and social domains. Brain networks are known to exhibit community structure at a variety of scales-local, meso, and global scale. However, modularity, while useful in describing mesoscale brain organization, is limited as a metric to a global scale describing the overall strength of community structure.
View Article and Find Full Text PDFMol Ther
August 2025
Sarah Cannon Research Institute at Health ONE, Denver, CO 80218, USA.
Vocimagene amiretrorepvec (Toca 511) is a replicating retroviral vector (RRV) encoding cytosine deaminase that converts 5-fluorocytosine (5-FC) into 5-fluorouracil in the tumor microenvironment. This study investigated the safety and immunomodulatory effects of systemically administered Toca 511 and Toca FC in advanced cancer patients. Eligible subjects received three daily intravenous (i.
View Article and Find Full Text PDFJ Immunother Cancer
June 2025
Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Purpose: SWOG S1609 ual nti-CTLA-4 and anti-PD-1 blockade in are umors (DART) studied the efficacy of ipilimumab combined with nivolumab across multiple rare tumor types. We report the results of the pancreatic neuroendocrine neoplasm (PNEN) cohort.
Experimental Design: Treatment consisted of ipilimumab 1 mg/kg intravenously every 6 weeks with nivolumab 240 mg intravenously every 2 weeks.
Gesundheitswesen
July 2025
Institut für Geschichte, Theorie und Ethik der Medizin, Heinrich-Heine-Universität Düsseldorf, Medizinische Fakultät, Düsseldorf, Germany.
This article examines the impact of the 1975 expert report on psychiatric care in Germany (Psychiatry Enquete) through the analysis of oral history interviews. From the memories of contemporary witnesses, we reconstruct their perspectives on the reform process surrounding the Psychiatry Enquete and its effects. Our aim is to contribute to a nuanced understanding of the Enquete and its complex effects on psychiatric practice and reform dynamics.
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