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Background/objectives: Persons with Parkinson's disease (PD) are at elevated risk of falling due to deficits in postural control, lower limb strength, and sensory integration. While community-based boxing programs (CBPs) have shown promise in improving strength and balance, their feasibility and potential role in addressing fall risk remain unclear. This preliminary, prospective cohort study explored the feasibility of a CBP enhanced with individualized balance training tailored to somatosensory deficits and explored early indications of potential impact on fall risk and related outcomes.
Methods: Twenty individuals with mild-to-moderate PD participated in a 12-week exercise program consisting of group-based boxing, functional circuit training, and one-on-one balance training based on the Modified Clinical Test of Sensory Interaction in Balance. Self-reported falls were collected at baseline and 3 months post-intervention. Secondary outcomes included standard measures of balance, gait, and functional mobility.
Results: Participants demonstrated significant improvements in balance and functional mobility including the Timed Up and Go (F(2, 40.85) = 24.83, < 0.001, η = 0.580), Five Times Sit-to-Stand Test (F(2, 78.13) = 50.22, < 0.001, η = 0.736), and Berg Balance Scale (F(2, 193.39) = 12.72, < 0.001, η = 0.414), among others. 4 participants experienced a decrease in falls, 2 experienced an increase, and the remainder had no change.
Conclusions: These preliminary findings suggest that integrating individualized balance training with a CBP is feasible and may positively influence functional mobility and balance in persons with PD. However, effects on fall reduction remain inconclusive. These results should be interpreted as exploratory and used to inform the design of future structured clinical trials.
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http://dx.doi.org/10.3390/brainsci15080858 | DOI Listing |
Background: The study aimed to adapt a stress and well-being intervention delivered via a mobile health (mHealth) app for Latinx Millennial caregivers. This demographic, born between 1981 and 1996, represents a significant portion of caregivers in the United States, with unique challenges due to higher mental distress and poorer physical health compared to non-caregivers. Latinx Millennial caregivers face additional barriers, including higher uninsured rates and increased caregiving burdens.
View Article and Find Full Text PDFPLoS One
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Toronto Rehabilitation Institute - University Health Network, Toronto, Ontario, Canada.
Stroke significantly contributes to long-term disability, one of the problems is with impaired balance control, increasing the risk of falls. The risk of falls may be mitigated using reactive balance training (RBT) which has been shown to effectively reduce fall risk by enhancing reactive stepping following repeated balance perturbations. However, the optimal RBT intensity for people with chronic stroke remains unknown.
View Article and Find Full Text PDFPolicy optimization methods are promising to tackle high-complexity reinforcement learning (RL) tasks with multiple agents. In this article, we derive a general trust region for policy optimization methods by considering the effect of subpolicy combinations among agents in multiagent environments. Based on this trust region, we propose an inductive objective to train the policy function, which can ensure agents learn monotonically improving policies.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug De
Proliferative retinopathy is a leading cause of irreversible blindness in humans; however, the molecular mechanisms behind the immune cell-mediated retinal angiogenesis remain poorly elucidated. Here, using single-cell RNA sequencing in an oxygen-induced retinopathy (OIR) model, we identified an enrichment of sorting nexin (SNX)-related pathways, with SNX3, a member of the SNX family that is involved in endosomal sorting and trafficking, being significantly upregulated in the myeloid cell subpopulations of OIR retinas. Immunostaining showed that SNX3 expression is markedly increased in the retinal microglia/macrophages of mice with OIR, which is mainly located within and around the neovascular tufts.
View Article and Find Full Text PDFJ Strength Cond Res
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Institute for Data Analysis and Process Design, ZHAW, Zurich, Switzerland; and.
Achermann, BB, Drewek, A, and Lorenzetti, SR. Acute effect of the bounce squat on ground reaction force at the turning point and barbell kinematics. J Strength Cond Res XX(X): 000-000, 2025-The free-weight back squat is a key exercise for developing lower-body strength, with variations that influence muscle activation and performance.
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