Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The development of biodegradable nanocarriers has long been a priority for researchers and medical professionals in the realm of drug delivery. Because of their inherent benefits, which include superior biocompatibility, customizable degradability, easy surface functionalization, and stealth-like behavior, polylactic acid-hyperbranched polyglycerol (PLA-HPG) copolymers have demonstrated a promising future in the field of biomedical research. The synthesis of PLA-HPG copolymers and the creation of their nanoparticles for biomedical uses have been the focus of current efforts. In this review, we summarize the synthetic strategies of PLA-HPG copolymers and corresponding nanoparticles, and highlight their physicochemical properties, biocompatibility, and degradation properties. Furthermore, we introduce a number of PLA-HPG nanoparticles that are utilized for surface skin delivery, wound dressing, and in vivo drug delivery biological applications. Finally, we conclude by offering our thoughts on how this nanoplatform might advance in the future.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12384396 | PMC |
| http://dx.doi.org/10.3390/bios15080502 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Synthesis and Biomedical Applications of PLA-HPG-Based Biodegradable Nanocarriers: A Review.
Biosensors (Basel)
August 2025
Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China.
The development of biodegradable nanocarriers has long been a priority for researchers and medical professionals in the realm of drug delivery. Because of their inherent benefits, which include superior biocompatibility, customizable degradability, easy surface functionalization, and stealth-like behavior, polylactic acid-hyperbranched polyglycerol (PLA-HPG) copolymers have demonstrated a promising future in the field of biomedical research. The synthesis of PLA-HPG copolymers and the creation of their nanoparticles for biomedical uses have been the focus of current efforts.
View Article and Find Full Text PDFAnti-seed PNAs targeting multiple oncomiRs for brain tumor therapy.
Sci Adv
February 2023
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA.
Glioblastoma (GBM) is one of the most lethal malignancies with poor survival and high recurrence rates. Here, we aimed to simultaneously target oncomiRs 10b and 21, reported to drive GBM progression and invasiveness. We designed short (8-mer) γ-modified peptide nucleic acids (sγPNAs), targeting the seed region of oncomiRs 10b and 21.
View Article and Find Full Text PDFSkin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures.
J Adv Res
February 2022
Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China.
Background: Skin cancer has been the leading type of cancer worldwide. Melanoma and non-melanoma skin cancers are now the most common types of skin cancer that have been reached to epidemic proportion. Based on the rapid prevalence of skin cancers, and lack of efficient drug delivery systems, it is essential to surge the possible ways to prevent or cure the disease.
View Article and Find Full Text PDFNanoparticle-mediated intratumoral inhibition of miR-21 for improved survival in glioblastoma.
Biomaterials
May 2019
Department of Biomedical Engineering, Yale University, New Haven, CT 06510, United States. Electronic address:
Article Synopsis
- Glioblastoma (GBM) is a really aggressive brain tumor that's hard to treat, and current treatments aren't helping much.
- Scientists created tiny particles called nanoparticles that can deliver special drugs directly to the tumor, helping to block a harmful molecule called miR-21 that makes the cancer worse.
- These nanoparticles showed that they can effectively reach the cancer cells, help make them die, and when tested on animals, they improved survival when used with traditional chemotherapy.
Systemic delivery of blood-brain barrier-targeted polymeric nanoparticles enhances delivery to brain tissue.
J Drug Target
July 2016
a Department of Biomedical Engineering .
Delivery of therapeutic agents to the central nervous system is a significant challenge, hindering progress in the treatment of diseases such as glioblastoma. Due to the presence of the blood-brain barrier (BBB), therapeutic agents do not readily transverse the brain endothelium to enter the parenchyma. Previous reports suggest that surface modification of polymer nanoparticles (NPs) can improve their ability to cross the BBB, but it is unclear whether the observed enhancements in transport are large enough to enhance therapy.
View Article and Find Full Text PDF