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Accurate transmission of chromatin states during DNA replication is central to epigenetic inheritance. Recent advances have illuminated mechanisms by which parental histones, which carry key post-translational modifications, are recycled and redistributed to daughter strands. This review synthesizes emerging insights into the molecular machinery that mediates histone recycling during replication. It highlights the interplay between histone chaperones and replication factors and examines how perturbations in these pathways influence heterochromatin inheritance. The fission yeast serves as a powerful model for recent investigations, revealing new principles that are conserved across eukaryotes.
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http://dx.doi.org/10.1016/j.cellin.2025.100275 | DOI Listing |
Cell Insight
October 2025
Department of Biological Sciences, Columbia University, New York, NY, 10027, USA.
Accurate transmission of chromatin states during DNA replication is central to epigenetic inheritance. Recent advances have illuminated mechanisms by which parental histones, which carry key post-translational modifications, are recycled and redistributed to daughter strands. This review synthesizes emerging insights into the molecular machinery that mediates histone recycling during replication.
View Article and Find Full Text PDFChromosome Res
July 2025
Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK.
Centromeres provide the chromosomal scaffold for the assembly of the kinetochore complex, thereby linking replicated sister chromatids to the mitotic spindle, driving their segregation into nascent daughter cells. The location and maintenance of centromeres rely, in large part, on a unique conserved chromatin domain, defined by nucleosomes containing the histone H3 variant, Centromere Protein A (CENP-A), whose discovery 40 years ago we now celebrate. Current models place CENP-A, along with many of its orthologs, at the centre of a self-propagating epigenetic feedback loop that heritably maintains centromere position through mitotic and meiotic divisions.
View Article and Find Full Text PDFFront Cell Dev Biol
May 2025
Department of Medicinal Chemistry, Medical University of Bialystok, Bialystok, Poland.
Although the role of proline (Pro) in regulatory mechanisms of cell metabolism is well recognized, the interest in metabolic significance of hydroxyproline (Hyp) has received little attention. Hyp was considered as a waste metabolite of protein degradation, mainly degradation of collagen. This amino acid is not synthesized and is not incorporated into proteins.
View Article and Find Full Text PDFEnviron Int
July 2025
Laboratory of Environmental Medicine and Developmental Toxicology, Shantou University Medical College, Shantou 515041 Guangdong, PR China; Department of Digestive Surgery, the First Affiliated Hospital of Shantou University Medical College, Shantou 515000 Guangdong, PR China. Electronic address: gcc
Informal e-waste recycling releases airborne particulate matter (PM) and polycyclic aromatic hydrocarbons (PAHs), which are linked to intestinal barrier dysfunction and chronic inflammation. SIRT6, a histone deacetylase, modulates inflammation by suppressing NF-κB signaling, but its role in mitigating e-waste pollutant-induced childhood enteritis remains unclear. This cross-sectional study evaluated associations between e-waste exposure, intestinal inflammation, and SIRT6 levels in 217 preschool children from Guiyu (e-waste-exposed, n = 109) and Haojiang (non-exposed control, n = 108), China.
View Article and Find Full Text PDFAutophagy
May 2025
Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Weill Cornell Medicine, Houston, TX, USA.
Macroautophagy (autophagy) is an evolutionarily conserved process that degrades excess cytoplasmic components, such as protein aggregates and damaged organelles, by encapsulating them within double-membrane autophagosomes. These autophagosomes undergo distinct stages - initiation, phagophore nucleation, expansion, and closure - before fusing with lysosomes (or occasionally endosomes) for degradation and recycling. This process is regulated by ATG (autophagy related) proteins, which govern autophagosome formation and lysosomal fusion.
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