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Ectopic pancreas is a rare condition where pancreatic tissue develops outside its normal location, often remaining asymptomatic. We present a case of a 45-year-old woman with type 2 diabetes and hypertension who presented with postprandial abdominal pain, projectile vomiting, and constipation, clinically suggestive of intestinal obstruction. Computed tomography revealed jejunal wall thickening, raising suspicion of a neoplastic lesion. Exploratory laparotomy identified a 4 cm sessile mass in the jejunum, which was resected. Histopathology confirmed ectopic pancreatic tissue (Type I) with acini, ducts, and islets in the submucosa and muscularis, causing luminal narrowing. The patient recovered well after surgery, with complete symptom resolution. This case highlights ectopic pancreas as a rare but important differential for small bowel obstruction, requiring histopathological confirmation for definitive diagnosis. Surgical resection remains the treatment of choice for symptomatic cases.
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http://dx.doi.org/10.1093/jscr/rjaf645 | DOI Listing |
J Obes
September 2025
School of Natural Sciences, University of Lincoln, Lincoln, UK.
To investigate the genetic determinants of fat distribution across anatomical sites and their implications for health outcomes. We analyzed neck-to-knee MRI data from the UK Biobank ( = 37,589) to measure fat at various locations and used Mendelian randomization to assess effects on 26 obesity-related diseases and 94 biomarkers from FinnGen and other consortia. We identified genetic loci associated with 10 fat depots: abdominal subcutaneous adipose tissue ( = 2 loci), thigh subcutaneous adipose tissue (25), thigh intermuscular adipose tissue (15), visceral adipose tissue (7), liver proton density fat fraction (PDFF) (8), pancreas PDFF (11), paraspinal adipose tissue (9), pelvic bone marrow fat (28), thigh bone marrow fat (27), and vertebrae bone marrow fat (5).
View Article and Find Full Text PDFAm J Physiol Endocrinol Metab
August 2025
"Aldo Ravelli" Center for Neurotechnology and Experimental Brain Therapeutics, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.
Cystic Fibrosis (CF) is a genetic disease that primarily affects the pancreas and lungs. CF dyslipidaemia is characterized by decreased circulating lipids and increased ectopic lipid deposition in liver, pancreas, and lungs. Pancreatic exocrine insufficiency precedes the onset of CF related diabetes (CFRD).
View Article and Find Full Text PDFJ Surg Case Rep
August 2025
Department of General Surgery, Mamata Academy of Medical Sciences, Hyderabad 500118, India.
Ectopic pancreas is a rare condition where pancreatic tissue develops outside its normal location, often remaining asymptomatic. We present a case of a 45-year-old woman with type 2 diabetes and hypertension who presented with postprandial abdominal pain, projectile vomiting, and constipation, clinically suggestive of intestinal obstruction. Computed tomography revealed jejunal wall thickening, raising suspicion of a neoplastic lesion.
View Article and Find Full Text PDFJ Surg Case Rep
August 2025
Department of Thoracic Surgery at Jersey Shore University Medical Center (JSUMC), 1945 Route 33, Neptune, NJ 07753, United States.
Ectopic pancreas (EP) is a rare congenital anomaly defined as pancreatic tissue lacking anatomical or vascular continuity with the pancreas. Although it occurs in 0.25%-2% of the population, mediastinal EP is exceedingly rare, with fewer than 30 reported cases.
View Article and Find Full Text PDFTrends Endocrinol Metab
August 2025
Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging (Shandong First Medical University), Ministry of Education, Jinan, 250021, China; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, 250021, China; Shandong Institute of Endocrine & Metabolic Diseases,
Since the introduction of the concept of 'lipotoxicity' 30 years ago, it has become widely accepted that ectopic triglyceride deposition is a key contributor to metabolic diseases. Subsequently, clinical observations have also revealed that triglyceride deposition can occur in a wide range of tissues and organs, including liver, pancreas, kidney, bone, thyroid and sex glands. However, these ectopic triglycerides were long regarded as inert reservoirs.
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