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Purpose: To explore the safety and efficacy of cervical cerclage for asymptomatic twin pregnancies with a newly diagnosed short cervix between 24 and 27 weeks' gestation.
Methods: Eighty-six pregnant women with asymptomatic twin pregnancies and a newly diagnosed short cervix at 24-27 gestational weeks were divided into two groups based on receipt of ultrasound-indicated cerclage (UIC). The primary outcome was gestational age at birth. Secondary outcomes included spontaneous preterm birth (sPTB) rates and neonatal outcomes.
Results: Forty-seven participants received UIC and 39 comprised the control group. The UIC group demonstrated a significantly prolonged diagnosis-to-birth interval, higher gestational age at birth, improved ongoing pregnancy survival curve, and lower risk of sPTB at <36, 34, 32, 30, and 28 weeks compared to controls. Neonates in the UIC group had higher birth weights, lower risk of birth weight <1500 g, and reduced neonatal intensive care unit (NICU) admission rates.
Conclusion: UIC performed at 24-27 weeks for asymptomatic twin pregnancies with a newly diagnosed short cervix can prolong gestation, reduce severe sPTB, and improve short-term perinatal outcomes.
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http://dx.doi.org/10.1007/s00404-025-08165-6 | DOI Listing |
J Obstet Gynaecol Res
September 2025
Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Aims: Preterm delivery (PTD) is a leading cause of neonatal morbidity and mortality. Accurate prediction is crucial for optimizing clinical outcomes, particularly in women with a short cervix. Although fetal fibronectin (FFN) is widely used to predict PTD, placental alpha-microglobulin-1 (PAMG-1) has gained attention for its potential to improve predictive accuracy.
View Article and Find Full Text PDFArch Gynecol Obstet
August 2025
Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, West Gaoke Road 2699, Shanghai, 200092, China.
Purpose: To explore the safety and efficacy of cervical cerclage for asymptomatic twin pregnancies with a newly diagnosed short cervix between 24 and 27 weeks' gestation.
Methods: Eighty-six pregnant women with asymptomatic twin pregnancies and a newly diagnosed short cervix at 24-27 gestational weeks were divided into two groups based on receipt of ultrasound-indicated cerclage (UIC). The primary outcome was gestational age at birth.
Front Pediatr
August 2025
Department of Clinical Genetics, Odense Universitetshospital, Odense, Denmark.
Introduction: Vanishing White Matter disease (VWM) is a rare neurological disease, with an autosomal recessive inheritance. In this case report, we describe two four-year-old dizygotic twin brothers diagnosed with VWM with the same genotype and different phenotypes. We also describe a new likely pathogenic variant leading to VWM.
View Article and Find Full Text PDFNeurogenetics
August 2025
Human Genetics Lab, Altamedica Main Centre, Viale Liegi 45, Rome, 00198, Italy.
Type 2 Long QT Syndrome (type 2 LQTS) is a cardiac channelopathy caused by pathogenic variants in the KCNH2 gene, often associated with delayed cardiac repolarization and increased risk of arrhythmias. While its impact is traditionally considered cardiac, emerging studies suggest a potential role of KCNH2 dysfunction in neurogical disorders. We describe monozygotic twin sisters carrying the pathogenic frameshift variant KCNH2 c.
View Article and Find Full Text PDFBest Pract Res Clin Obstet Gynaecol
September 2025
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, UPMC Magee-Women's Hospital, Pittsburgh, PA, USA. Electronic address:
Selective fetoscopic laser photocoagulation of communicating vessels (SFPL) is well established as the first line of therapy for stage II-IV twin-twin transfusion syndrome (TTTS). The optimal management of stage I TTTS is less well-defined. While many stage I patients resolve spontaneously or remain stage I with good pregnancy outcomes, a majority progress to higher stages.
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