Multimodal Positron Emission Tomography/Computed Tomography Radiomics Combined with a Clinical Model for Preoperative Prediction of Invasive Pulmonary Adenocarcinoma in Ground-Glass Nodules.

Rationale And Objectives: To develop and validate predictive models based on F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) radiomics and a clinical model for differentiating invasive adenocarcinoma (IAC) from non-invasive ground-glass nodules (GGNs) in early-stage lung cancer.

Materials And Methods: A total of 164 patients with GGNs histologically confirmed as part of the lung adenocarcinoma spectrum (including both invasive and non-invasive subtypes) who underwent preoperative F-FDG PET/CT and surgery. Radiomic features were extracted from PET and CT images. Models were constructed using support vector machine (SVM), random forest (RF), and extreme gradient boosting (XGBoost). Five predictive models (CT, PET, PET/CT, Clinical, Combined) were evaluated using receiver operating characteristic (ROC) curves, decision curve analysis (DCA), and calibration curves. Statistical comparisons were performed using DeLong's test, net reclassification improvement (NRI), and integrated discrimination improvement (IDI).

Results: The Combined model, integrating PET/CT radiomic features with the clinical model, achieved the highest diagnostic performance (AUC: 0.950 in training, 0.911 in test). It consistently showed superior IDI and NRI across both cohorts and significantly outperformed the clinical model (DeLong p = 0.027), confirming its enhanced predictive power through multimodal integration. A clinical nomogram was constructed from the final model to support individualized risk stratification.

Conclusion: Integrating PET/CT radiomic features with a clinical model significantly enhances the preoperative prediction of GGN invasiveness. This multimodal image data may assist in preoperative risk stratification and support personalized surgical decision-making in early-stage lung adenocarcinoma.