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Article Abstract
A concise enantioselective total synthesis of leptosphine C () has been achieved. Our synthetic strategy features an unprecedented diastereo-/enantioselective Hajos-Parrish-Eder-Sauer-Wiechert (HPESW) reaction for construction of the AB ring system with continuous stereogenic centers (76% yield, 90% ee, dr = 19:1) and an uncommon Pauson-Khand (PK) reaction of geminal dimethyl alkenyl side chains for establishing the CD ring system with the quaternary carbon at C14.
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| http://dx.doi.org/10.1021/acs.orglett.5c03236 | DOI Listing |
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